The histone lysine methyltransferase DOT1L (DOT1-like histone lysine methyltransferase) is
responsible for the epigenetic regulation of gene expression through specific methylation of …

Acute myeloid leukaemias harbouring a rearrangement of the mixed lineage leukaemia
gene (MLL) are aggressive haematopoietic malignancies that relapse early and have a poor …

Packaging of the eukaryotic genome with histone and other proteins forms a chromatin
structure that regulates the outcome of all DNA mediated processes. The cellular pathways …

Histone methyltransferase DOT1L is an attractive therapeutic target for the treatment of
hematological malignancies. Here, we report the design, synthesis, and profiling of new …

To assess telomere silencing 1-like (DOTIL) gene expression within gastric cancer (GC)
tissues as well as its function of promoting cancer stem cell (CSC)-mediated epithelial …

Epigenetics “above or over genetics” is the term used for processes that result in
modifications which are stably inherited through cell generations, without changing the …

Post-translational modifications of histones (PTMs) are key epigenetic regulators and control
chromatin-mediated processes such as gene expression, genome organization, DNA …

目的通过生物信息学预测DOT1L 基因在胃癌(gastric cancer, GC) 中的增殖信号通路,
探讨其对胃癌细胞增殖的可能机制. 方法从TCGA 数据库中下载GC 基因表达数据及临床数据 …

Cancer is among the most common causes of death in the world. Despite the recent
breakthroughs over the last few decades, further research studies are required to improve …

The ubiquitylation of histone H2B at Lys (K) 120 is known to be associated with methylation
of H3K4 and H3K79, transcription elongation, and DNA repair. Mechanistic studies of …