Abstract The Framingham Heart Study (FHS) has conducted seminal research defining
cardiovascular disease (CVD) risk factors and fundamentally shaping public health …

Objectives: The purpose of this study was to estimate the effect of long-term exposure to
lower plasma low-density lipoprotein cholesterol (LDL-C) on the risk of coronary heart …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Background: Relative risk reduction with statin therapy has been consistent across nearly all
subgroups studied to date. However, in analyses of 2 randomized controlled primary …

To dissect the genetic architecture of blood pressure and assess effects on target organ
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 …

Intima-media thickness (IMT) provides a surrogate end point of cardiovascular outcomes in
clinical trials evaluating the efficacy of cardiovascular risk factor modification. Carotid artery …

Genome-wide association studies have greatly improved our understanding of the genetic
basis of disease risk. The fact that they tend not to identify more than a fraction of the specific …

Body mass and body fat composition are of clinical interest due to their links to
cardiovascular-and metabolic diseases. Fat stored in the trunk has been suggested to be …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …