In ischemic stroke, the primary neuronal injury caused by the disruption of energy supply is
further exacerbated by secondary sterile inflammation. The inflammatory cascade is largely …

Despite continuous advances in understanding the underlying pathogenesis of
hyperexcitable networks and lowered seizure thresholds, the treatment of epilepsy remains …

Nitrogen-containing heterocyclic compounds and their derivatives have historically been
invaluable as a source of therapeutic agents. Pyrazole, which has two nitrogen atoms and …

Subcortical brain structures are integral to motion, consciousness, emotions and learning.
We identified common genetic variation related to the volumes of the nucleus accumbens …

Alkaline phosphatases are found in different living species and play crucial roles in various
significant functions, such as hydrolyzing a variable spectrum of phosphate‐containing …

In recent years, a substantial body of evidence has emerged demonstrating that purine and
pyrimidine synthesis and metabolism play major roles in controlling embryonic and fetal …

Tissue-nonspecific alkaline phosphatase (TNAP) is a key enzyme responsible for skeletal
tissue mineralization. It is involved in the dephosphorylation of various physiological …

Hyperinflammation plays an important role in severe and critical COVID-19. Using
inconsistent criteria, many researchers define hyperinflammation as a form of very severe …

Etiology of the Alzheimer's disease (AD) is not fully understood. Different pathological
processes are considered, such as amyloid deposition, tau protein phosphorylation …

Much progress has been made over the last few decades in the identification of new anti-
epileptic drugs (AEDs). However, 30% of epilepsy patients suffer poor seizure control. This …