Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key
roles in the development of many organs and tissues, and are deregulated in birth defects …

Lithium salts have been in the therapeutic toolbox for better or worse since the 19th century,
with purported benefit in gout, hangover, insomnia, and early suggestions that lithium …

The transcription factor GLI3 is a member of the Hedgehog (Hh/HH) signaling pathway that
can exist as a full length (Gli3-FL/GLI3-FL) or repressor (Gli3-R/GLI3-R) form. In response to …

Glycogen synthase kinase (GSK) 3β is a multifunctional serine/threonine protein kinase with
more than 100 substrates and interacting molecules. GSK3β is normally active in cells and …

Gliomas originate from glial cells and are the most frequent primary brain tumors. High-
grade gliomas occur∼ 4 times more frequently than low-grade gliomas, are highly …

GLI transcription factors have important roles in intracellular signaling cascade, acting as the
main mediators of the HH-GLI signaling pathway. This is one of the major developmental …

GSK3α and GSK3β are two GSK3 isoforms with 84% overall identity and 98% identity in
their catalytic domains. GSK3β plays important roles in the pathogenesis of cancer, while …

Aberrant activation of hedgehog (Hh) signaling has been observed in a wide variety of
tumors and accounts for more than 25% of human cancer deaths. Inhibitors targeting the Hh …

The Hedgehog (Hh)-glioma-associated oncogene homolog (GLI) signaling pathway is
highly conserved among mammals, with crucial roles in regulating embryonic development …

Simple Summary The current obstacles for discovering new drugs for cancer therapy have
necessitated the development of the alternative strategy of drug repurposing, the …