Microbial Synthetic Epigenetic Tools Design and Applications
Microbial synthetic epigenetics offers significant opportunities for the design of synthetic
biology tools by leveraging reversible gene control mechanisms without altering DNA …
biology tools by leveraging reversible gene control mechanisms without altering DNA …
Reversible switching and stability of the epigenetic memory system in bacteria
In previous work, we have developed a DNA methylation‐based epigenetic memory system
that operates in Escherichia coli to detect environmental signals, trigger a phenotypic switch …
that operates in Escherichia coli to detect environmental signals, trigger a phenotypic switch …
DNA methylation in prokaryotes
J Casadesús, MA Sánchez-Romero - DNA Methyltransferases-Role and …, 2022 - Springer
The genomes of bacteria, archaea, and phage contain small amounts of C5-methylcytosine,
N4-methylcytosine, and N6-methyladenine. Base methylation takes place after DNA …
N4-methylcytosine, and N6-methyladenine. Base methylation takes place after DNA …
Model-based design of a synthetic oscillator based on an epigenetic methylation memory system
Oscillations are an important component in biological systems; grasping their mechanisms
and regulation, however, is difficult. Here, we use the theory of dynamical systems to support …
and regulation, however, is difficult. Here, we use the theory of dynamical systems to support …
Hysteresis and bistability in synaptic transmission modeled as a chain of biochemical reactions with a positive feedback
P Katauskis, F Ivanauskas, A Alaburda - Nonlinear Analysis: Modelling …, 2024 - zurnalai.vu.lt
In this paper, we employ computational analysis to investigate the long-term potentiation
(LTP) and memory formation in synapses between neurons. We use a mathematical model …
(LTP) and memory formation in synapses between neurons. We use a mathematical model …
Mathematical Model of Synaptic Long-Term Potentiation as a Bistability in a Chain of Biochemical Reactions with a Positive Feedback
P Katauskis, F Ivanauskas, A Alaburda - Acta Biotheoretica, 2023 - Springer
Nitric oxide (NO) is involved in synaptic long-term potentiation (LTP) by multiple signaling
pathways. Here, we show that LTP of synaptic transmission can be explained as a feature of …
pathways. Here, we show that LTP of synaptic transmission can be explained as a feature of …
[PDF][PDF] A hybrid population model enables the study of single-cell heterogeneity in an epigenetic memory system.
Single-cells measurement techniques like flow cytometry allow heterogeneity in biological
systems to be quantified efficiently. However, many modelling approaches currently cannot …
systems to be quantified efficiently. However, many modelling approaches currently cannot …