The fork protection complex promotes parental histone recycling and epigenetic memory
The inheritance of parental histones across the replication fork is thought to mediate
epigenetic memory. Here, we reveal that fission yeast Mrc1 (CLASPIN in humans) binds H3 …
epigenetic memory. Here, we reveal that fission yeast Mrc1 (CLASPIN in humans) binds H3 …
Mechanisms of Inheritance of Chromatin States: From Yeast to Human
HD Madhani - Annual Review of Biophysics, 2025 - annualreviews.org
In this article I review mechanisms that underpin epigenetic inheritance of CpG methylation
and histone H3 lysine 9 methylation (H3K9me) in chromatin in fungi and mammals. CpG …
and histone H3 lysine 9 methylation (H3K9me) in chromatin in fungi and mammals. CpG …
Monitoring and quantifying replication fork dynamics with high-throughput methods
N Fajri, N Petryk - Communications Biology, 2024 - nature.com
Before each cell division, eukaryotic cells must replicate their chromosomes to ensure the
accurate transmission of genetic information. Chromosome replication involves more than …
accurate transmission of genetic information. Chromosome replication involves more than …
Molecular mechanism of parental H3/H4 recycling at a replication fork
F Nagae, Y Murayama, T Terakawa - Nature Communications, 2024 - nature.com
In chromatin replication, faithful recycling of histones from parental DNA to replicated strands
is essential for maintaining epigenetic information across generations. A previous …
is essential for maintaining epigenetic information across generations. A previous …
Structures of the human leading strand Polε–PCNA holoenzyme
In eukaryotes, the leading strand DNA is synthesized by Polε and the lagging strand by Polδ.
These replicative polymerases have higher processivity when paired with the DNA clamp …
These replicative polymerases have higher processivity when paired with the DNA clamp …
Four decades of Eukaryotic DNA replication: From yeast genetics to high-resolution cryo-EM structures of the replisome
BK Tye - Proceedings of the National Academy of Sciences, 2024 - pnas.org
I had my eyes set on DNA replication research when I took my first molecular biology course
in graduate school. My election to the National Academy of Sciences came just when I was …
in graduate school. My election to the National Academy of Sciences came just when I was …
Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2
S Gan, WS Yang, L Wei, Z Zhang, RM Xu - Science China Life Sciences, 2024 - Springer
The passage of DNA replication forks during eukaryotic cell division disrupts the
nucleosomes they encounter, and de novo assembly of nucleosomes onto replicated DNA …
nucleosomes they encounter, and de novo assembly of nucleosomes onto replicated DNA …
[HTML][HTML] The Role of the MCM2-7 Helicase Subunit MCM2 in Epigenetic Inheritance
J Jia, C Yu - Biology, 2024 - mdpi.com
Simple Summary The MCM2-7 helicase plays a crucial role in unwinding the double-
stranded DNA template during DNA replication. Recent studies indicate that the MCM2-7 …
stranded DNA template during DNA replication. Recent studies indicate that the MCM2-7 …
Identification of modulators of the ALT pathway through a native FISH-based optical screen
B Azeroglu, S Khurana, SC Wang, GM Tricola… - Cell Reports, 2025 - cell.com
A significant portion of human cancers utilize a recombination-based pathway, alternative
lengthening of telomeres (ALT), to extend telomeres. To gain further insights into this …
lengthening of telomeres (ALT), to extend telomeres. To gain further insights into this …
[HTML][HTML] Assembly, Activation, and Helicase Actions of MCM2-7: Transition from Inactive MCM2-7 Double Hexamers to Active Replication Forks
Z You, H Masai - Biology, 2024 - mdpi.com
Simple Summary MCM2-7, evolutionarily conserved and essential for DNA replication,
functions as the central factor for the eukaryotic replicative DNA helicase. Here, we …
functions as the central factor for the eukaryotic replicative DNA helicase. Here, we …