RNA has emerged as a revolutionary and important tool in the battle against emerging
infectious diseases, with roles extending beyond its applications in vaccines, in which it is …

In the past 4 years, RNA interference (RNAi) has become widely used as an experimental
tool to analyse the function of mammalian genes, both in vitro and in vivo. By harnessing an …

Double-stranded RNA can induce gene silencing via a process known as RNA interference
(RNAi). Previously, we have shown that stable expression of a single shRNA targeting the …

In less than a decade after discovery, RNA interference-mediated gene silencing is already
being tested as potential therapy in clinical trials for a number of diseases. Lentiviral vectors …

Objective—To investigate whether exposure of human monocytes/macrophages to tobacco
smoke induces their release of membrane microvesicles (MVs) that carry tissue factor (TF) …

Objective—Biologically significant amounts of two procoagulant molecules,
phosphatidylserine (PS) and tissue factor (TF), are transported by monocyte/macrophage …

HIV‐1‐infected opiate abusers often exhibit an accelerated form of HIV‐1‐associated
dementia and enhanced neurological dysfunction. Productive HIV‐1 infection of microglia …

Foot-and-mouth disease virus (FMDV) is an economically devastating viral disease leading
to a substantial loss to the swine industry worldwide. A novel alternative strategy is to …

RNA interference (RNAi) is a natural cellular process that regulates gene expression by a
highly precise mechanism of sequence-directed gene silencing at the stage of translation by …

Background RNA interference (RNAi) has proven to be a powerful tool to suppress gene
expression and can be used as a therapeutic strategy against human pathogenic viruses …