Three-way junction skeleton biosensors based on aptamers, DNAzymes, and DNA hybridization probes

H Zahraee, Z Khoshbin, F Mohammadi… - TrAC Trends in …, 2023 - Elsevier
Nucleic acids can be used as building blocks for highly regular and complex structures at
the nanoscale due to their inherent self-assembly and programmability resulting from intra …

Plant protoplasts in the age of synthetic biology

I Reyna-Llorens, M Ferro-Costa… - Journal of experimental …, 2023 - academic.oup.com
Protoplasts, which are plant cells with their cell walls removed, have been used for decades
in plant research and have been instrumental in genetic transformation and the study of …

Phosphorothioated DNA Engineered Liposomes as a General Platform for Stimuli‐Responsive Cell‐Specific Intracellular Delivery and Genome Editing

A Yan, X Chen, J He, Y Ge, Q Liu… - Angewandte Chemie …, 2023 - Wiley Online Library
Intracellular protein delivery is highly desirable for protein drug‐based cell therapy.
Established technologies suffer from poor cell‐specific cytosolic protein delivery, which …

Current state of human gene therapy: approved products and vectors

AY Shchaslyvyi, SV Antonenko, MG Tesliuk… - Pharmaceuticals, 2023 - mdpi.com
In the realm of gene therapy, a pivotal moment arrived with Paul Berg's groundbreaking
identification of the first recombinant DNA in 1972. This achievement set the stage for future …

A Semisynthetic Bioluminescence Sensor for Ratiometric Imaging of Metal Ions In Vivo Using DNAzymes Conjugated to An Engineered Nano‐Luciferase

M Xiong, Y Wu, G Kong, W Lewis, Z Yang… - Angewandte …, 2023 - Wiley Online Library
DNA‐based probes have gained significant attention as versatile tools for biochemical
analysis, benefiting from their programmability and biocompatibility. However, most existing …

Aptamer‐Assisted Blockade of the Immune Suppressor Sialic Acid‐Binding Immunoglobulin‐Like Lectin‐15 for Cancer Immunotherapy

Q Wu, X Wei, F Chen, M Huang… - Angewandte Chemie …, 2023 - Wiley Online Library
The percentage of low response and adaptive resistance to current antibody‐based immune
checkpoint blockade (ICB) therapy requires the development of novel immunotherapy …

Emerging sensing, imaging, and computational technologies to scale nano-to macroscale rhizosphere dynamics–Review and research perspectives

AH Ahkami, O Qafoku, T Roose, Q Mou, Y Lu… - Soil Biology and …, 2024 - Elsevier
The soil region influenced by plant roots, ie, the rhizosphere, is one of the most complex
biological habitats on Earth and significantly impacts global carbon flow and transformation …

A fluorescence aptasensor based on hybridization chain reaction for simultaneous detection of T-2 toxins and zearalenone1

W Zhu, G Ji, R Chen, Y Xiang, S Ji, S Zhang, Z Gao… - Talanta, 2023 - Elsevier
It is extremely necessary to establish a rapid and high-throughput method to detect
mycotoxins in food, because grains and cereals are greatly vulnerable to mycotoxins before …

Inhibition of Cell Motility by Cell-Penetrating Dynamic Covalent Cascade Exchangers: Integrins Participate in Thiol-Mediated Uptake

F Coelho, S Saidjalolov, D Moreau, O Thorn-Seshold… - JACS Au, 2023 - ACS Publications
Integrins are cell surface proteins responsible for cell motility. Inspired by the rich disulfide
exchange chemistry of integrins, we show here the inhibition of cell migration by cascade …

Delivering DNA Aptamers Across the Blood–Brain Barrier Reveals Heterogeneous Decreased ATP in Different Brain Regions of Alzheimer's Disease Mouse Models

M Banik, AP Ledray, Y Wu, Y Lu - ACS Central Science, 2024 - ACS Publications
DNA aptamers have been developed as sensors to detect metabolites with high sensitivity,
selectivity, and biocompatibility. While they are effective in sensing important targets in the …