Breast cancer remains a leading cause of cancer-related mortality in women, reflecting
profound disease heterogeneity, metastasis, and therapeutic resistance. Over the last …

The 17th St Gallen International Breast Cancer Consensus Conference in 2021 was held
virtually, owing to the global COVID-19 pandemic. More than 3300 participants took part in …

Background The recurrence score based on the 21-gene breast-cancer assay has been
clinically useful in predicting a chemotherapy benefit in hormone-receptor–positive, human …

PURPOSE To update recommendations on appropriate use of breast cancer biomarker
assay results to guide adjuvant endocrine and chemotherapy decisions in early-stage breast …

Despite recent therapeutic advances in cancer treatment, metastasis remains the principal
cause of cancer death. Recent work has uncovered the unique biology of metastasis …

Introduction Extensive research is directed to uncover new biomarkers capable to stratify
breast cancer patients into clinically relevant cohorts. However, the overall performance …

Importance Axillary lymph node metastasis (ALNM) status, typically estimated using an
invasive procedure with a high false-negative rate, strongly affects the prognosis of …

Highlights•Breast cancer in young women should be treated based on stage and biology of
disease.•Management of breast cancer in young women requires special considerations …

Providing prognostic information at the time of cancer diagnosis has important implications
for treatment and monitoring. Although cancer staging, histopathological assessment …

Background Recent data suggest that human epidermal growth factor receptor 2 (HER2)-
low breast cancer may represent a distinct entity. We aimed to compare disease …