Abstract Purpose: SN-38, a metabolite of irinotecan hydrochloride (CPT-11), is considered to
play a key role in the development of diarrhea as well as in the antitumor activity of CPT-11 …

[57] ABSTRACT A-and/or B-ring substituted camptothecin derivatives, which are poorly
water soluble (less than 5 micrograms per milliliter of Water), are highly lipophilic …

C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen
atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho-or …

hydroxy 7-ethyl camptothecin (HECPT), an active metabolite of the camptothecin analog
CPT-11, is poorly soluble in water. Because of its poor water solu bility, HECPT has not …

Vinorelbine is a semi-synthetic vinca alkaloid which was initially developed in France in the
1980's. Due to its unique structure it is considerably less neurotoxic than vincristine. Several …

57 ABSTRACT A-and/or B-ring Substituted camptothecin derivatives, which are poorly water
Soluble (less than 5 micrograms per milliliter of water), are highly lipophilic camptothecin …

57 ABSTRACT The novel compounds 11-hydroxy-7-ethyl camptothecin and 11-hydroxy-7-
methoxy camptothecin (11.7-HECPT and 11.7-HMCPT) are active anticancer compounds …

57 ABSTRACT A-and/or B-ring Substituted camptothecin derivatives, which are poorly water
Soluble (less than 5 micrograms per milliliter of water), are highly lipophilic camptothecin …

Our increasing knowledge on the pathogenetic mechanisms involved in the growth of
cancer cells and on the molecular basis of cancer has influenced the development of …

Bowel dysfunction, such as diarrhoea and constipation, can be a disturbing side-effect in
chemotherapy that may result not only in significant physical and emotional distress for the …