Parkinson's disease is a neurodegenerative disease caused by the death of neurons, ie,
cells critical to the production of dopamine, an important neurotransmitter in the brain. Here …

Highlights•Homeostatic plasticity plays an important role in mitigating striatal
pathophysiology in the early stages of PD.•Aberrant dopamine-dependent synaptic plasticity …

The loss of nigrostriatal dopamine neurons in Parkinson's disease induces a reduction in the
number of dendritic spines on medium spiny neurons (MSNs) of the striatum expressing D1 …

The striatum is densely innervated by mesencephalic dopaminergic neurons that modulate
acquisition and vigor of goal-directed actions and habits. This innervation is progressively …

The dorsolateral striatum (DLS) receives excitatory inputs from both sensory and motor
cortical regions. In the neocortex, sensory responses are affected by motor activity, however …

The striatum is richly innervated by mesencephalic dopaminergic neurons that modulate a
diverse array of cellular and synaptic functions that control goal-directed actions and habits …

Classical schemes of basal ganglia organization posit that parkinsonian movement
difficulties presenting after striatal dopamine depletion stem from the disproportionate firing …

Parkinson's disease (PD) is a movement disorder caused by the loss of dopaminergic
innervation, particularly to the striatum. PD patients often exhibit sensory impairments, yet …

Background Numerous studies indicate an association between neurodegenerative and
metabolic diseases. Although still a matter of debate, growing evidence from …

Evidence suggests that synapses are affected first in Parkinson's disease (PD). Here, we
tested the claim that pathological accumulation of α-synuclein, and subsequent synaptic …