Plant‐derived extracellular vesicles: Recent advancements and current challenges on their use for biomedical applications

MQ Lian, WH Chng, J Liang, HQ Yeo… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) represent a diverse class of lipid bilayer membrane vesicles
released by both animal and plant cells. These ubiquitous vesicles are involved in …

Prospects of plant-derived exosome-like nanocarriers in oncology and tissue engineering

S Rahmati, H Karimi, M Alizadeh, AH Khazaei… - Human Cell, 2024 - Springer
Almost all cell types, either in vivo or in vitro, create extracellular vesicles (EVs). Among them
are exosomes (EXOs), ie, tiny nanovesicles containing a lipid bilayer, proteins, and RNAs …

Hyaluronic acid-coated bovine milk exosomes for achieving tumor-specific intracellular delivery of miRNA-204

D Li, L Gong, H Lin, S Yao, Y Yin, Z Zhou, J Shi, Z Wu… - Cells, 2022 - mdpi.com
Cell type-specific drug delivery is a straightforward strategy to achieve targeted cancer
therapy and reduce side effects. Hyaluronic acid (HA), an US Food and Drug Administration …

Unraveling the surface marker signature of cell-derived vesicles via proteome analysis and nanoparticle flow cytometry

HC Lau, I Passalacqua, JH Jung, Y Kwon, D Zocco… - Scientific Reports, 2024 - nature.com
The cell-derived vesicles (CDVs) obtained using a proprietary extrusion process are the
foundation of BioDrone platform technology. With superior productivity and versatility, this …

Biomimetic hybrid nanovesicles improve infected diabetic wound via enhanced targeted delivery

G Jiang, J Guo, C Yan, Y He, J Chen, M Zhang… - Journal of Controlled …, 2024 - Elsevier
Infected diabetic wounds have been raising the global medical burden because of its high
occurrence and resulting risk of amputation. Impaired endothelium has been well …

Extracellular Vesicles and Their Mimetics: A Comparative Study of Their Pharmacological Activities and Immunogenicity Profiles

WH Chng, RPK Muthuramalingam, CKL Lou, S New… - Pharmaceutics, 2023 - mdpi.com
Extracellular vesicles (EVs), which are miniaturised carriers loaded with functional proteins,
lipids, and nucleic acid material, are naturally secreted by cells and show intrinsic …

Exosomes as Novel Delivery Systems for Application in Traditional Chinese Medicine

Q Chen, D Wu, Y Wang, Z Chen - Molecules, 2022 - mdpi.com
Exosomes, as gifts of nature derived from various cell types with a size range from~ 40 to
160 nm in diameter, have gained attention recently. They are composed of a lipid membrane …

Evodiamine-loaded rhEGF-conjugated bovine serum albumin nanoparticles alleviate indomethacin-associated gastric mucosal injury in male SD rats

S Wang, Y Jin, Q Zhao, T Wu, M Zhang, S Song… - Journal of Drug Delivery …, 2023 - Elsevier
Gastric mucosal injury, the most common adverse effect of non-steroidal anti-inflammatory
drugs, severely threatens human health. Existing therapeutic drugs face many challenges …

[HTML][HTML] Emerging Strategies for Revascularization: Use of Cell-Derived Extracellular Vesicles and Artificial Nanovesicles in Critical Limb Ischemia

VM Ravi Mythili, RL Rajendran, R Arun… - Bioengineering, 2025 - mdpi.com
Critical limb ischemia (CLI) poses a substantial and intricate challenge in vascular medicine,
necessitating the development of innovative therapeutic strategies to address its …

Extracellular vesicles as a novel photosensitive drug delivery system for enhanced photodynamic therapy

L Tong, S Zhang, R Huang, H Yi… - … in Bioengineering and …, 2022 - frontiersin.org
Photodynamic therapy (PDT) is a promising non-invasive therapeutic approach that utilizes
photosensitizers (PSs) to generate highly reactive oxygen species (ROS), including singlet …