The crystalline lens plays an important role in the refractive vision of vertebrates by
facilitating variable fine focusing of light onto the retina. Loss of lens transparency, or …

The absence of cellular organelles in fiber cells and very high cytoplasmic protein
concentration (up to 900 mg/ml) minimize light scattering in the lens and ensure its …

Purpose: This research was undertaken to document the changes in the organization and
properties of human lens lipid membranes that occur with age. Methods: Human lens lipid …

αH-Crystallin, a high molecular weight form of α-crystallin, is one of the major proteins in the
lens nucleus. This high molecular weight aggregate (HMWA) plays an important role in the …

Down syndrome (DS) is the most common chromosomal disorder in humans. DS is
associated with increased prevalence of several ocular sequelae, including characteristic …

Abstract Background Human alphaB crystallin (HspB5) contains the alpha crystallin core
domain, a series of antiparallel beta-strands organized into the characteristic beta sandwich …

Cataract is one of the most prevalent protein aggregation disorders and still the most
common cause of vision loss worldwide. The metabolically quiescent core region of the …

The “superpower” of invisibility is a reality and a necessity for many animals that live in
featureless environments like the open ocean, where there is nowhere to hide. How do …

Cataract disease is strongly associated with progressively accumulating oxidative damage
to the extremely long-lived crystallin proteins of the lens. Cysteine oxidation affects crystallin …

Highly concentrated lens proteins, mostly β-and γ-crystallin, are responsible for maintaining
the structure and refractivity of the eye lens. However, with aging and cataract formation, β …