Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …

Mendelian susceptibility to mycobacterial diseases confers predisposition to clinical disease
caused by weakly virulent mycobacterial species in otherwise healthy individuals. Since …

An international panel of experts prepared an evidenced-based guideline for vaccination of
immunocompromised adults and children. These guidelines are intended for use by primary …

Primary immunodeficiencies (PIDs) were long thought to be exclusively recessive traits—
autosomal recessive (AR) in most cases, with a few X-linked recessive (XR) diseases. In …

Immunocompromised patients have increased susceptibility to vaccine-preventable
infections. Thus, vaccination is a critical issue in this population. Vaccines are usually …

Primary immunodeficiency diseases (PIDs) are a group of inherited disorders, characterized
by defects of the immune system predisposing individuals to variety of manifestations …

Abstract Autosomal recessive interleukin (IL)-12 p40 (IL-12p40) deficiency is a rare genetic
etiology of Mendelian susceptibility to mycobacterial disease (MSMD). We report the …

Background Bacillus Calmette-Guérin (BCG) vaccine is a live attenuated bacterial vaccine
derived from Mycobacterium bovis, which is mostly administered to neonates in regions …

Hereditary haemophagocytic lymphohistiocytosis (HLH) is a fatal inflammatory disease and
treatments currently may lead to serious side effects. There is a pressing need for effective …

Background The number of inherited diseases and the spectrum of clinical manifestations of
primary immunodeficiency disorders (PIDs) are ever-expanding. Molecular diagnosis using …