Role of pyroptosis in cardiovascular disease

Z Zhaolin, L Guohua, W Shiyuan, W Zuo - Cell proliferation, 2019 - Wiley Online Library
Cardiac function is determined by the dynamic equilibrium of various cell types and the
extracellular matrix that composes the heart. Cardiovascular diseases (CVDs), especially …

Role of cytokines and inflammation in heart function during health and disease

M Bartekova, J Radosinska, M Jelemensky… - Heart failure …, 2018 - Springer
By virtue of their actions on NF-κB, an inflammatory nuclear transcription factor, various
cytokines have been documented to play important regulatory roles in determining cardiac …

Exosome treatment enhances anti-inflammatory M2 macrophages and reduces inflammation-induced pyroptosis in doxorubicin-induced cardiomyopathy

DK Singla, TA Johnson, Z Tavakoli Dargani - Cells, 2019 - mdpi.com
Doxorubicin (Dox) is an effective antineoplastic agent used to treat cancers, but its use is
limited as Dox induces adverse cardiotoxic effects. Dox-induced cardiotoxicity (DIC) can …

Effects of curcumin nanoparticles in isoproterenol‐induced myocardial infarction

PM Boarescu, I Chirilă, AE Bulboacă… - Oxidative medicine …, 2019 - Wiley Online Library
Curcumin has anti‐inflammatory, antioxidative, anticarcinogenic, and cardiovascular
protective effects. Our study is aimed at evaluating the effects of pretreatment with curcumin …

Liraglutide attenuates NLRP3 inflammasome-dependent pyroptosis via regulating SIRT1/NOX4/ROS pathway in H9c2 cells

A Chen, Z Chen, Y Xia, D Lu, X Yang, A Sun… - Biochemical and …, 2018 - Elsevier
The glucagon-like peptide-1 analog liraglutide has been proved to exert cardioprotective
role via activating prosurvival pathways and suppressing inflammation. The activation of …

Dioscin and diosgenin: Insights into their potential protective effects in cardiac diseases

X Li, S Liu, L Qu, Y Chen, C Yuan, A Qin, J Liang… - Journal of …, 2021 - Elsevier
Background and ethnopharmacological relevance Dioscin and diosgenin derived from
plants of the genus Dioscoreaceae such as D. nipponica and D. panthaica Prain et Burk …

An injectable thermosensitive hydrogel loaded with an ancient natural drug colchicine for myocardial repair after infarction

Y Chen, J Shi, Y Zhang, J Miao, Z Zhao, X Jin… - Journal of Materials …, 2020 - pubs.rsc.org
Localized administration of anti-inflammatory agents benefits patients after myocardial
infarction (MI) by repressing/modulating inflammatory response of the MI region and thus …

Association between C-reactive protein levels at hospital admission and long-term mortality in patients with acute decompensated heart failure

H Matsumoto, T Kasai, A Sato, S Ishiwata, S Yatsu… - Heart and vessels, 2019 - Springer
The C-reactive protein (CRP) levels obtained at hospital admission are associated with the
prognosis of several cardiovascular diseases, including acute coronary syndrome. Although …

Targeting necroptosis as therapeutic potential in chronic myocardial infarction

C Piamsiri, C Maneechote, N Siri-Angkul… - Journal of biomedical …, 2021 - Springer
Cardiovascular diseases (CVDs) are considered the predominant cause of morbidity and
mortality globally. Of these, myocardial infarction (MI) is the most common cause of CVD …

Inflammation in myocardial injury: mesenchymal stem cells as potential immunomodulators

W Yan, E Abu-El-Rub, S Saravanan… - American Journal …, 2019 - journals.physiology.org
Ischemic heart disease is a growing worldwide epidemic. Improvements in medical and
surgical therapies have reduced early mortality after acute myocardial infarction and …