Over the past 16 years, genetic code expansion and reprogramming in living organisms has
been transformed by advances that leverage the unique properties of pyrrolysyl-tRNA …

Aging is the result of the accumulation of a wide variety of molecular and cellular damage
over time. This has been associated with a number of features termed hallmarks of aging …

SIRT7, a sirtuin family member implicated in aging and disease, is a regulator of metabolism
and stress responses. It remains elusive how human somatic stem cell populations might be …

A generalizable strategy with programmable site specificity for in situ profiling of histone
modifications on unperturbed chromatin remains highly desirable but challenging. We …

Abstract Background Histone deacetylases (HDACs) are one of the essential epigenetic
targets in cancer treatment. These enzymes play key roles in post-translation modification …

Various post-translational modifications can naturally occur on proteins, regulating the
activity, subcellular localization, interaction, or stability of the proteins. However, it can be …

Post‐translational modifications (PTMs) of proteins not only exponentially increase the
diversity of proteoforms, but also contribute to dynamically modulating the localization …

Sirtuins are key players of metabolic stress response. Originally described as deacetylases,
some sirtuins also exhibit poorly understood mono–adenosine 5′-diphosphate (ADP) …

Adaptation to different forms of environmental stress is crucial for maintaining essential
cellular functions and survival. The nucleolus plays a decisive role as a signaling hub for …

Post-translational modifications (PTMs) endow proteins with new properties to respond to
environmental changes or growth needs. With the development of advanced proteomics …