The control of sleep and wakefulness by mesolimbic dopamine systems

Y Oishi, M Lazarus - Neuroscience research, 2017 - Elsevier
The mesolimbic dopamine pathway between the ventral tegmental area (VTA) and the
nucleus accumbens (NAc) plays a central role in motivational behaviors. Recent findings …

Rapid, transient synaptic plasticity in addiction

CD Gipson, YM Kupchik, PW Kalivas - Neuropharmacology, 2014 - Elsevier
Chronic use of addictive drugs produces enduring neuroadaptations in the corticostriatal
glutamatergic brain circuitry. The nucleus accumbens (NAc), which integrates cortical …

Contrasting forms of cocaine-evoked plasticity control components of relapse

V Pascoli, J Terrier, J Espallergues, E Valjent… - Nature, 2014 - nature.com
Nucleus accumbens neurons serve to integrate information from cortical and limbic regions
to direct behaviour. Addictive drugs are proposed to hijack this system, enabling drug …

VTA glutamatergic inputs to nucleus accumbens drive aversion by acting on GABAergic interneurons

J Qi, S Zhang, HL Wang, DJ Barker… - Nature …, 2016 - nature.com
The ventral tegmental area (VTA) is best known for its dopamine neurons, some of which
project to nucleus accumbens (nAcc). However, the VTA also has glutamatergic neurons …

[HTML][HTML] Nucleus accumbens neurons expressing dopamine D1 receptors modulate states of consciousness in sevoflurane anesthesia

WW Bao, W Xu, GJ Pan, TX Wang, Y Han, WM Qu… - Current Biology, 2021 - cell.com
Although general anesthesia (GA) enables patients to undergo surgery without
consciousness, the precise neural mechanisms underlying this phenomenon have yet to be …

Sex steroid hormones, the estrous cycle, and rapid modulation of glutamatergic synapse properties in the striatal brain regions with a focus on 17β-estradiol and the …

SB Proaño, CK Miller, AA Krentzel, DM Dorris… - Steroids, 2024 - Elsevier
The striatal brain regions encompassing the nucleus accumbens core (NAcc), shell (NAcs)
and caudate-putamen (CPu) regulate cognitive functions including motivated behaviors …

[HTML][HTML] Nucleus accumbens in the pathogenesis of major depressive disorder: a brief review

Y Jiang, M Zou, Y Wang, Y Wang - Brain Research Bulletin, 2023 - Elsevier
Major depressive disorder (MDD) is the most prevalent mental disorder characterized by
anhedonia, loss of motivation, avolition, behavioral despair and cognitive abnormalities …

Glucagon-like peptide-1 receptor activation in the nucleus accumbens core suppresses feeding by increasing glutamatergic AMPA/kainate signaling

EG Mietlicki-Baase, PI Ortinski, DJ Reiner… - Journal of …, 2014 - Soc Neuroscience
Glucagon-like peptide-1 receptor (GLP-1R) activation in the nucleus accumbens (NAc) core
is pharmacologically and physiologically relevant for regulating palatable food intake. Here …

Monoamines: dopamine, norepinephrine, and serotonin, beyond modulation,“switches” that alter the state of target networks

SA Azizi - The Neuroscientist, 2022 - journals.sagepub.com
How do monoamines influence the perceptual and behavioral aspects of brain function? A
library of information regarding the genetic, molecular, cellular, and function of monoamines …

Ca2+-modulated photoactivatable imaging reveals neuron-astrocyte glutamatergic circuitries within the nucleus accumbens

I Serra, J Esparza, L Delgado… - Nature …, 2022 - nature.com
Astrocytes are key elements of brain circuits that are involved in different aspects of the
neuronal physiology relevant to brain functions. Although much effort is being made to …