Recent efforts to synthetically expand drug‐like chemical libraries have led to the
emergence of unprecedently large virtual databases. This surge of make‐on‐demand …

Breast cancer (BCa) is one of the most predominantly diagnosed cancers in women.
Notably, 70% of BCa diagnoses are Estrogen Receptor α positive (ERα+) making it a critical …

Prostate cancer (PCa) is a leading cause of death for men in North America. The androgen
receptor (AR)-a hormone inducible transcription factor-drives expression of tumor promoting …

Computational modelling remains an indispensable technique in drug discovery. With
myriad of high computing resources, and improved modelling algorithms, there has been a …

Increased levels of metal ions in human seminal fluid have a significant correlation with
male fertility. Few publications explain the effect of metals in semen and their influence on …

Endocrine-disrupting chemicals (EDCs) can compete with endogenous hormones and bind
to the orthosteric site of nuclear receptors (NRs), affecting normal endocrine system function …

The purpose of this review is to highlight recent developments in small molecules and
peptides that block the binding of coactivators to steroid receptors. These coactivator binding …

17β-estradiol (E2) exerts its physiological effects through the estrogen receptor α (ie, ERα).
The E2: ERα signaling allows the regulation of cell proliferation. Indeed, E2 sustains the …

The development of new antiandrogens, such as enzalutamide, or androgen synthesis
inhibitors like abiraterone has improved patient outcomes in the treatment of advanced …

Up to 40% of patients with estrogen receptor (ER)-positive breast cancer will develop
resistance against the majority of current ER-directed therapies. Resistance can arise …