summary Great progress continues to be made in our understanding of the multiple facets of
osteoarthritis (OA) biology. Here, we review the major advances in this field and progress …

Peroxiredoxins are multifunctional enzymes that play a key role in protecting cells from
stresses and maintaining the homeostasis of many cellular processes. Peroxiredoxins were …

Objectives Prior studies noted that chondrocyte SIRT6 activity is repressed in older
chondrocytes rendering cells susceptible to catabolic signalling events implicated in …

Objective The purpose of this study was to investigate the effect of age and oxidative stress
on regulation of nuclear factor erythroid-2-related factor 2 (Nrf2) in young, old, and …

Due to their glycolytic nature and limited vascularity, nucleus pulposus (NP) cells of the
intervertebral disc and articular chondrocytes were long thought to have minimal reliance on …

NP cells of the intervertebral disc and articular chondrocytes reside in avascular and hypoxic
tissue niches. As a consequence of these environmental constraints the cells are primarily …

1 Online Supplementary Materials 1 2 Cartilage-specific Sirt6 deficiency represses IGF-1 and
enhances osteoarthritis severity in Page 1 1 Online Supplementary Materials 1 2 …