Several hereditary neurological and neuromuscular diseases are caused by an abnormal
expansion of trinucleotide repeats. To date, there have been 10 of these trinucleotide repeat …

Polyanionic lipopolysaccharides (LPS) play an important role in regulating the permeability
of the outer membrane (OM) of Gram-negative bacteria. Impairment of the LPS-enriched OM …

Under certain cellular conditions, functional proteins undergo misfolding, leading to a
transition into oligomers which precede the formation of amyloid fibrils. Misfolding proteins …

Pathogenic Rhodococcus equi release the virulence‐associated protein A (VapA) within
macrophage phagosomes. VapA permeabilizes phagosome and lysosome membranes and …

Huntington's disease (HD) is a fatal disorder associated with germline trinucleotide repeat
expansions in the HTT gene and characterised by striatal neurodegeneration. No efficacious …

Lipid membranes have recently been implicated in protein misfolding and disease etiology,
including for α-synuclein and Parkinson's disease. However, studying the intersection of …

Cholesterol (Chol) content in most cellular membranes does not exceed 50 mol%, only in
the eye lens's fiber cell plasma membrane, its content surpasses 50 mol%. At this high …

Huntington disease (HD) is an inherited neurodegenerative disease caused by the
expansion beyond a critical threshold of a polyglutamine (polyQ) tract near the N-terminus of …

Huntington's disease (HD) is a neurodegenerative disease resulting from an expansion of
the polyglutamine (polyQ) domain within the huntingtin protein (htt). PolyQ expansion …

Necroptosis is a subtype of regulated necrosis that occurs when caspases are inhibited or
fail to activate. Stimulus of cell death receptors results in a signaling cascade that triggers …