Osteonecrosis of the femoral head (ONFH) is a potentially disabling orthopedic condition
that requires total hip arthroplasty in most late-stage cases. However, mechanisms …

Skeletal quantity and quality are determined by processes of bone modeling and
remodeling, which are undertaken by cells that build and resorb bone as they respond to …

Scaffold-based bone tissue engineering strategies fail to meet the clinical need to fabricate
patient-specific and defect shape-specific, anatomically relevant load-bearing bone …

Abstract Aberrant Ras homologous (Rho) GTPase signalling is a major driver of cancer
metastasis, and GTPase-activating proteins (GAPs), the negative regulators of RhoGTPases …

Class IX myosins are simultaneously motor and signaling molecules. In addition to myosin
class-specific functions of the tail region, they feature unique motor properties. Within their …

Introduction: Myosin IXB (MYO9B) is an unconventional myosin with RhoGAP activity and
thus is a regulator of actin cytoskeletal organization. MYO9B was previously shown to be …

Rho GTPases play essential roles in various life activities. Rho GTPase-activating protein
(RhoGAP) and Rho guanine nucleotide exchange factor (RhoGEF) are the main regulators …

Objective. Delays in skeletal maturity are related to bone mass and fracture risk in children,
but the factors that determine it are unknown. We aimed to identify the association between …

The objective of this study was to examine relationships among a variety of bone
characteristics, including volumetric, mineral density, geometric, dynamic mechanical …

ARHGAP21 is a member of the RhoGAP family of proteins involved in cell growth,
differentiation, and adhesion. We have previously shown that the heterozygous Arhgap21 …