Single-cell transcriptome analysis highlights a role for neutrophils and inflammatory macrophages in the pathogenesis of severe COVID-19
Cumulative data link cytokine storms with coronavirus disease 2019 (COVID-19) severity.
The precise identification of immune cell subsets in bronchoalveolar lavage (BAL) and their …
The precise identification of immune cell subsets in bronchoalveolar lavage (BAL) and their …
Protein coding and long noncoding RNA (lncRNA) transcriptional landscape in SARS-CoV-2 infected bronchial epithelial cells highlight a role for interferon and …
The global spread of COVID-19, caused by pathogenic severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) underscores the need for an imminent response from medical …
coronavirus 2 (SARS-CoV-2) underscores the need for an imminent response from medical …
In situ mapping identifies distinct vascular niches for myelopoiesis
In contrast to nearly all other tissues, the anatomy of cell differentiation in the bone marrow
remains unknown. This is owing to a lack of strategies for examining myelopoiesis—the …
remains unknown. This is owing to a lack of strategies for examining myelopoiesis—the …
ANPELA: Significantly Enhanced Quantification Tool for Cytometry‐Based Single‐Cell Proteomics
Y Zhang, H Sun, X Lian, J Tang, F Zhu - Advanced science, 2023 - Wiley Online Library
ANPELA is widely used for quantifying traditional bulk proteomic data. Recently, there is a
clear shift from bulk proteomics to the single‐cell ones (SCP), for which powerful cytometry …
clear shift from bulk proteomics to the single‐cell ones (SCP), for which powerful cytometry …
Mouse models of neutropenia reveal progenitor-stage-specific defects
DE Muench, A Olsson, K Ferchen, G Pham, RA Serafin… - Nature, 2020 - nature.com
Advances in genetics and sequencing have identified a plethora of disease-associated and
disease-causing genetic alterations. To determine causality between genetics and disease …
disease-causing genetic alterations. To determine causality between genetics and disease …
An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors
Abstract Analysis of the human hematopoietic progenitor compartment is being transformed
by single-cell multimodal approaches. Cellular indexing of transcriptomes and epitopes by …
by single-cell multimodal approaches. Cellular indexing of transcriptomes and epitopes by …
Single-cell long noncoding RNA (lncRNA) transcriptome implicates MALAT1 in triple-negative breast cancer (TNBC) resistance to neoadjuvant chemotherapy
Cumulative evidence suggests added benefit for neoadjuvant chemotherapy (NAC) in a
subset of triple-negative breast cancer (TNBC) patients. Herein we identified the long …
subset of triple-negative breast cancer (TNBC) patients. Herein we identified the long …
Single-cell analysis of neonatal HSC ontogeny reveals gradual and uncoordinated transcriptional reprogramming that begins before birth
Fetal and adult hematopoietic stem cells (HSCs) have distinct proliferation rates, lineage
biases, gene expression profiles, and gene dependencies. Although these differences are …
biases, gene expression profiles, and gene dependencies. Although these differences are …
Cell fate dynamics and genomic programming of plasma cell precursors
GK Manakkat Vijay, H Singh - Immunological reviews, 2021 - Wiley Online Library
This review is focused on the cellular dynamics and genomic programming of plasma cell
(PC) precursors that arise during germinal center (GC) B cell responses in secondary …
(PC) precursors that arise during germinal center (GC) B cell responses in secondary …
Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions
M Solomon, B Song, V Govindarajah, S Good… - Journal of Experimental …, 2023 - rupress.org
The dynamics of the hematopoietic flux responsible for blood cell production in native
conditions remains a matter of debate. Using CITE-seq analyses, we uncovered a distinct …
conditions remains a matter of debate. Using CITE-seq analyses, we uncovered a distinct …