Sirtuin-1 (SIRT1) is a class-III histone deacetylase (HDAC), an NAD+-dependent enzyme
deeply involved in gene regulation, genome stability maintenance, apoptosis, autophagy …

Efficient S phase entry is essential for development, tissue repair, and immune defences.
However, hyperactive or expedited S phase entry causes replication stress, DNA damage …

Oxidative DNA damage constitutes a major threat to genetic integrity, and has thus been
implicated in the pathogenesis of a wide variety of diseases, including cancer and …

Resveratrol is reported to extend lifespan, and provide cardio-neuro-protective, anti-diabetic,
and anti-cancer effects, by initiating a stress response that induces survival genes. Because …

Efficient entry into S phase of the cell cycle is necessary for embryonic development and
tissue homoeostasis. However, unscheduled S phase entry triggers DNA damage and …

Ketone bodies (KBs) and Sirtuin-1 (SIRT1) have received increasing attention over the past
two decades given their pivotal function in a variety of biological contexts, including …

Throughout the process of carcinogenesis, cancer cells develop intricate networks to adapt
to a variety of stressful conditions including DNA damage, nutrient deprivation, and hypoxia …

Macroautophagy is a process in which cytoplasmic components, including whole
organelles, are degraded within lysosomes. Basally, this process is essential for …

Diabetic ulcers, a difficult problem faced by clinicians, are strongly associated with an
increase in cellular senescence. Few empirical studies have focused on exploring a …

Abstract Emerging evidence indicates that 2, 2′, 4, 4′-tetrabromodiphenyl ether (BDE-47)
induces liver injury through enhanced ROS production and lymphocytic infiltration, which …