Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

Early mast cell (MC) infiltration has been reported in a wide range of human and animal
tumors particularly malignant melanoma and breast and colorectal cancer. The …

Recent clinical trials have demonstrated the ability to durably control cancer in some
patients by manipulating T lymphocytes. These immunotherapies are revolutionizing cancer …

Among cells present in the tumor microenvironment, activated fibroblasts termed cancer-
associated fibroblasts (CAFs), play a critical role in the complex process of tumor-stroma …

Among the various immunological and non-immunological tumor-promoting activities of
myeloid-derived suppressor cells (MDSCs), their immunosuppressive capacity remains a …

Abstract In tumors, Cancer-Associated Fibroblasts (CAFs) constitute the most prominent
component of the tumor microenvironment (TME). CAFs are heterogeneous and composed …

In the tumor microenvironment (TME), tumor cells are constantly evolving to reduce
neoantigen generation and the mutational burden to escape the anti-tumor response. This …

The tumor microenvironment (TME) is comprised of many different cell populations, such as
cancer-associated fibroblasts and various infiltrating immune cells, and non-cell …

Mast cells are tissue-resident, innate immune cells that play a key role in the inflammatory
response and tissue homeostasis. Mast cells accumulate in the tumor stroma of different …

The tumor microenvironment plays a pivotal role in tumor initiation and progression by
creating a dynamic interaction with cancer cells. The tumor microenvironment consists of …