Complement is an important component of the innate immune system that is crucial for
defense from microbial infections and for clearance of immune complexes and injured cells …

Ischemia/reperfusion injury is an unavoidable relevant consequence after kidney
transplantation and influences short term as well as long-term graft outcome. Clinically …

The complement cascade, traditionally considered an effector arm of innate immunity
required for host defense against pathogens, is now recognized as a crucial pathogenic …

The anaphylatoxin (AT) C3a, C5a and C5a-desArg are generally considered pro-
inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to …

Intravascular haemolysis is a fundamental feature of chronic hereditary and acquired
haemolytic anaemias, including those associated with haemoglobinopathies, complement …

Organ transplantation appears today to be the best alternative to replace the loss of vital
organs induced by various diseases. Transplants can, however, also be rejected by the …

The complement system is a collection of soluble and membrane-bound proteins that
together act as a powerful amplifier of the innate and adaptive immune systems. Although its …

Increasing evidence indicates an integral role for the complement system in the deleterious
inflammatory reactions that occur during critical phases of the transplantation process, such …

The aberrant activation of complement system in several kidney diseases suggests that this
pillar of innate immunity has a critical role in the pathophysiology of renal damage of …

Surgical trauma and ischemia reperfusion injury (IRI) are unavoidable aspects of any solid
organ transplant procedure. They trigger a multifactorial antigen-independent inflammatory …