More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis,
induce inflammation and control the immune response. Cytokines are secreted …

Since their discovery as key mediators of cytokine signaling, considerable progress has
been made in defining the structure-function relationships of Signal Transducers and …

Abstract Interleukin 6 (IL-6) is the major survival factor for myeloma tumor cells and induces
signaling through the STAT proteins. We report that one STAT family member, Stat3, is …

Since the cloning of interleukin (IL)-15 six years ago, there have been numerous studies
examining the molecular and cellular biology of this cytokine. IL-15 and IL-2 have similar …

Stat3, a member of STAT, is activated by a variety of cytokines such as IL-6 family of
cytokines, granulocyte CSF, epidermal growth factor, and leptin. A recent study with mice …

Abstract Signal Transducers and Activators of Transcription (STATs) are a family of
cytoplasmic proteins with roles as signal messengers and transcription factors that …

A variety of important cellular functions are regulated by cytokines. The Jak-STAT pathway is
one of the important signaling pathways downstream of cytokine receptors. Following …

Numerous reports suggest that IL-6 promotes survival and proliferation of multiple myeloma
(MM) cells through the phosphorylation of a cell signaling protein, STAT3. Thus, agents that …

Adult T-cell leukemia (ATL) is an aggressive T-cell malignancy caused by human T-cell
leukemia virus type 1 (HTLV-1) that develops through a multistep carcinogenesis process …

The incidence of lymphoma has gradually increased over previous decades, and it ranks
among the ten most prevalent cancers worldwide. With the development of targeted …