The field of reverse vaccinology developed as an outcome of the genome sequence
revolution. Following the introduction of live vaccinations in the western world by Edward …

In the last decades, many regional and country‐wide control programmes for Johne's
disease (JD) were developed due to associated economic losses, or because of a possible …

The increasing resistance of many microbial strains to antibiotics, delayed laboratory results,
and side effects of many chemotherapeutics has raised the need to search for sensitive …

Biologics have emerged as a powerful and diverse class of molecular and cell‐based
therapies that are capable of replacing enzymes, editing genomes, targeting tumors, and …

Paratuberculosis (pTB) is a chronic granulomatous enteritis caused by Mycobacterium
avium subsp. paratuberculosis (MAP) in a wide variety of domestic and wild animals. Control …

Current T cell epitope prediction tools are a valuable resource in designing targeted
immunogenicity experiments. They typically focus on, and are able to, accurately predict …

Background Detection of an appropriate antigen with high immunogenicity can be a big step
in the production of an effective vaccine for control of Johne's disease (JD). The aim of this …

Epitope mapping has emerged as a powerful tool to design vaccines. It proved itself a
number of times to reveal the building blocks of potent immuno-prophylactics. T-cell epitope …

Mycobacterium avium subspecies paratuberculosis (MAP) is a global concern in modern
livestock production worldwide. The available vaccines against paratuberculosis do not offer …

Despite its potential for early diagnosis of Mycobacterium avium subsp. paratuberculosis
(MAP) infection, the IFN-γ release assay is not used routinely, because of low specificity of …