Cyclin-dependent kinases (Cdks) are serine/threonine kinases and their catalytic activities
are modulated by interactions with cyclins and Cdk inhibitors (CKIs). Close cooperation …

Formation of the central nervous system requires a period of extensive progenitor cell
proliferation, accompanied or closely followed by differentiation; the balance between these …

A fundamental question in neurobiology is how the balance between proliferation and
differentiation of neuronal precursors is maintained to ensure that the proper number of …

Down syndrome (DS) is characterized by brain hypotrophy and intellectual disability starting
from early life stages. Accumulating evidence shows that the phenotypic features of the DS …

Background MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene
expression at the post-transcriptional level. miRNAs have emerged as important modulators …

Generation of neurons from patient fibroblasts using a combination of developmentally
defined transcription factors has great potential in disease modelling, as well as ultimately …

Attainment of the differentiated state during the final stages of somatic cell differentiation is
closely tied to cell cycle progression. Much less is known about the role of the cell cycle at …

The morphology of the adult brain is the result of a delicate balance between neural
progenitor proliferation and the initiation of neurogenesis in the embryonic period. Here we …

The ventral telencephalon is the developmental origin of the basal ganglia and the source of
neuronal and glial cells that integrate into developing circuits in other areas of the brain …

The CreER/LoxP system is widely accepted to track neural lineages and study gene
functions upon tamoxifen (TAM) administration. We have observed that prenatal TAM …