Steroid sulfatase (STS) is responsible for the hydrolysis of aryl and alkyl steroid sulfates and
therefore has a pivotal role in regulating the formation of biologically active steroids. The …

Starting from the very simple molecule sulfamic acid, O‐substituted‐, N‐substituted‐, or di‐
/tri‐substituted sulfamates may be obtained, which show specific biological activities which …

Steroid sulfatase (STS) regulates the local production of estrogens and androgens from
systemic precursors in several tissues. The enzyme catalyzes the hydrolysis of the sulfate …

The 17β-hydroxysteroid dehydrogenases (17β-HSDs) catalyze the interconversion between
the oxidized and reduced forms of androgens and estrogens at the 17 position. The 17β …

Background: Steroids play an important role in life because they can regulate a variety of
biological processes and have been widely used in medicine namely as antiinflammatory …

Hydrolysis of biologically inactive steroid sulfates to unconjugated steroids by steroid
sulfatase (STS) is strongly implicated in rendering estrogenic stimulation to hormone …

Introduction: Steroid sulfatase (STS) converts sulfated hormones to free hormones of
importance in hormone-dependent diseases such as breast cancer and endometriosis …

The interest in the introduction of the oxime group in molecules aiming to improve their
biological effects is increasing. This work aimed to develop new steroidal oximes of the …

The presence of estrone sulfatase in breast tumors and the high levels of circulating estrone
sulfate may contribute the major portion of estrogen synthesized locally in breast tissues …

Sulfamic acid, a rather simple molecule used widely by medicinal chemists for the design of
a host of derivatives with pharmacological applications, may give rise to at least four types of …