Prader–Willi syndrome (PWS) and Angelman syndrome (AS) are two distinct neurogenetic
disorders in which imprinted genes on the proximal long arm of chromosome 15 are …

The chromosomal region, 15q11-q13, involved in Prader-Willi and Angelman syndromes
(PWS and AS) represents a paradigm for understanding the relationships between genome …

Prader-Willi syndrome is a complex disorder affecting multiple systems with many
manifestations relating to hypothalamic insufficiency. Major findings include infantile …

Gametic imprinting is a developmental process that induces parental-specific expression or
repression of autosomal and X-chromosome-linked genes,. The mouse Igf2r gene …

Relative to genomes of other sequenced organisms, the human genome appears
particularly enriched for large, highly homologous segmental duplications (⩾ 90% sequence …

Genomic imprinting is a complex epigenetic process that contributes substantially to
embryogenesis, reproduction, and gametogenesis. Only small fraction of genes within the …

▪ Abstract A handful of autosomal genes in the mammalian genome are inherited in a silent
state from one of the two parents, and in a fully active form from the other, thereby rendering …

Prader–Willi syndrome (PWS) is a neurodevelopmental disorder that arises from lack of
expression of paternally inherited genes known to be imprinted and located in the …

Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are neurogenetic disorders that
are caused by the loss of function of imprinted genes in 15q11-q13. In a small group of …

Imprinted genes are marked in the germline and retain molecular memory of their parental
origin, resulting in allelic expression differences during development. Abnormalities in …