Establishing Chlamydomonas reinhardtii as an industrial biotechnology host

MA Scaife, GTDT Nguyen, J Rico, D Lambert… - The Plant …, 2015 - Wiley Online Library
Microalgae constitute a diverse group of eukaryotic unicellular organisms that are of interest
for pure and applied research. Owing to their natural synthesis of value‐added natural …

Engineering metabolism through dynamic control

N Venayak, N Anesiadis, WR Cluett… - Current opinion in …, 2015 - Elsevier
Highlights•Synthetic biology provides new tools for the dynamic control of
metabolism.•Dynamic control is crucial to further the field of metabolic engineering.•Sensors …

Genomically encoded analog memory with precise in vivo DNA writing in living cell populations

F Farzadfard, TK Lu - Science, 2014 - science.org
Introduction The conversion of transient information into long-lasting responses is a common
aspect of many biological processes and is crucial for the design of sophisticated synthetic …

Automated optogenetic feedback control for precise and robust regulation of gene expression and cell growth

A Milias-Argeitis, M Rullan, SK Aoki… - Nature …, 2016 - nature.com
Dynamic control of gene expression can have far-reaching implications for biotechnological
applications and biological discovery. Thanks to the advantages of light, optogenetics has …

Synthetic biological approaches for Optogenetics and tools for transcriptional Light‐control in bacteria

A Baumschlager, M Khammash - Advanced biology, 2021 - Wiley Online Library
Light has become established as a tool not only to visualize and investigate but also to steer
biological systems. This review starts by discussing the unique features that make light such …

Bacterial two-component systems as sensors for synthetic biology applications

JT Lazar, JJ Tabor - Current Opinion in Systems Biology, 2021 - Elsevier
Two-component systems (TCSs) are a ubiquitous family of signal transduction pathways that
enable bacteria to sense and respond to physical, chemical, and biological stimuli outside …

Refactoring and Optimization of Light-Switchable Escherichia coli Two-Component Systems

SR Schmidl, RU Sheth, A Wu, JJ Tabor - ACS synthetic biology, 2014 - ACS Publications
Light-switchable proteins enable unparalleled control of molecular biological processes in
live organisms. Previously, we have engineered red/far-red and green/red photoreversible …

Electronic control of gene expression and cell behaviour in Escherichia coli through redox signalling

T Tschirhart, E Kim, R McKay, H Ueda, HC Wu… - Nature …, 2017 - nature.com
The ability to interconvert information between electronic and ionic modalities has
transformed our ability to record and actuate biological function. Synthetic biology offers the …

Competition between histone and transcription factor binding regulates the onset of transcription in zebrafish embryos

SR Joseph, M Pálfy, L Hilbert, M Kumar, J Karschau… - elife, 2017 - elifesciences.org
Upon fertilization, the genome of animal embryos remains transcriptionally inactive until the
maternal-to-zygotic transition. At this time, the embryo takes control of its development and …

Programmable control of bacterial gene expression with the combined CRISPR and antisense RNA system

YJ Lee, A Hoynes-O'Connor, MC Leong… - Nucleic acids …, 2016 - academic.oup.com
A central goal of synthetic biology is to implement diverse cellular functions by predictably
controlling gene expression. Though research has focused more on protein regulators than …