In the wake of the success of modern immunotherapy, oncolytic viruses (OVs) are currently
seen as a potential therapeutic option for patients with cancer who do not respond or fail to …

Dengue virus (DENV) is a mosquito-borne Flavivirus that is endemic in many tropical and
sub-tropical countries where the transmission vectors Aedes spp. mosquitoes resides. There …

Vaccines have had broad medical impact, but existing vaccine technologies and production
methods are limited in their ability to respond rapidly to evolving and emerging pathogens …

Immunotherapies directly enhancing anti-tumor CD8+ T cell responses have yielded
measurable but limited success, highlighting the need for alternatives. Anti-tumor T cell …

The use of DNA and viral vector-based vaccines for the induction of cellular immune
responses is increasingly gaining interest. However, concerns have been raised regarding …

Interferon (IFN) response is the first line of host defense against virus infection. The recent
years have witnessed tremendous progress in understanding of fish IFN antiviral response …

Many highly effective vaccines have been produced against viruses whose virulent infection
elicits strong and durable protective immunity. In these cases, characterization of immune …

Mosquito-borne arboviruses cause serious diseases in humans that are increasingly
becoming public health problems, yet arbovirus infections cause minimal pathology in the …

The type I interferon (IFN) system induces inhibition of viral replication, but can also activate
the innate and adaptive immune system. An important role of the type I IFN system in …

RIG-I-like receptors (RLRs: RIG-I, MDA5 and LGP2) play a major role in the innate immune
response against viral infections and detect patterns on viral RNA molecules that are …