Three-dimensional molecular structures can provide detailed information on biological
mechanisms and, for cases in which the molecular function affects human health, can …

A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy
of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the …

The integration of a DNA copy of the viral RNA genome into host chromatin is the defining
step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded …

To complete its life cycle, HIV-1 enters the nucleus of the host cell as reverse-transcribed
viral DNA. The nucleus is a complex environment, in which chromatin is organized to …

This book grew out of a scientific review, originally published in Microbiological Reviews. It
has been updated and expanded-now citing more than 2100 references (100 pages of the …

During eukaryotic transcription elongation, RNA polymerase II (RNAP2) is regulated by a
chorus of factors. Here, we identified a common binary interaction module consisting of TFIIS …

Chromosomal integration enables human immunodeficiency virus (HIV) to establish a
permanent reservoir that can be therapeutically suppressed but not eradicated. Participation …

LEDGF/p75 directly interacts with lentiviral integrase proteins and can modulate their
enzymatic activities and chromosomal association. A novel genetic knockout model was …

Integrase (IN) is an essential retroviral enzyme, and human transcriptional coactivator p75,
which is also referred to as lens epithelium-derived growth factor (LEDGF), is the dominant …

Lens epithelium–derived growth factor p75 splice variant (LEDGF) is a chromatin-binding
protein known for its antiapoptotic activity and ability to direct human immunodeficiency virus …