Nanotherapeutics with immunoregulatory functions for the treatment of bacterial infection

D Yang, M Ding, Y Song, Y Hu, W Xiu… - Biomaterials …, 2023 - spj.science.org
The advent of drug-resistant pathogens results in the occurrence of stubborn bacterial
infections that cannot be treated with traditional antibiotics. Antibacterial immunotherapy by …

Development in the concept of bacterial polysaccharide repeating unit-based antibacterial conjugate vaccines

R Rohokale, Z Guo - ACS infectious diseases, 2023 - ACS Publications
The surface of cells is coated with a dense layer of glycans, known as the cell glycocalyx.
The complex glycans in the glycocalyx are involved in various biological events, such as …

Glycoconjugate vaccines against antimicrobial resistant pathogens

C Sorieul, M Dolce, MR Romano, J Codée… - Expert Review of …, 2023 - Taylor & Francis
Introduction Antimicrobial resistance (AMR) is responsible for the death of millions
worldwide and stands as a major threat to our healthcare systems, which are heavily reliant …

A Semisynthetic Oligomannuronic Acid-Based Glycoconjugate Vaccine against Pseudomonas aeruginosa

Y Zhang, X Wang, Y Liang, L Zhang, J Fan… - ACS Central …, 2024 - ACS Publications
Pseudomonas aeruginosa is one of the leading causes of nosocomial infections and has
become increasingly resistant to multiple antibiotics. However, development of novel …

Semi‐Synthetic Glycoconjugate Vaccine Lead Against Acinetobacter baumannii 17978

J Sianturi, P Priegue, J Hu, J Yin… - Angewandte Chemie …, 2022 - Wiley Online Library
Acinetobacter baumannii is a opportunistic bacterial pathogen responsible for serious
nosocomial infections that is becoming increasingly resistant against antibiotics. Capsular …

Carriers and antigens: new developments in glycoconjugate vaccines

RMF van der Put, B Metz, RJ Pieters - Vaccines, 2023 - mdpi.com
Glycoconjugate vaccines have proven their worth in the protection and prevention of
infectious diseases. The introduction of the Haemophilus influenzae type b vaccine is the …

Stereoselective Synthesis of the O‐antigen of A. baumannii ATCC 17961 Using Long‐Range Levulinoyl Group Participation

L Duan, Q Nie, Y Hu, L Wang, K Guo… - Angewandte …, 2023 - Wiley Online Library
Herein, we described the first synthesis of the pentasaccharide and decasaccharide of the A.
baumannii ATCC 17961 O‐antigen for developing a synthetic carbohydrate‐based vaccine …

Structural diversity among Acinetobacter baumannii K-antigens and its implication in the in silico serotyping

J Roshini, LPP Patro, S Sundaresan… - Frontiers in …, 2023 - frontiersin.org
Acinetobacter baumannii is an emerging opportunistic pathogen. It exhibits multi-, extreme-,
and pan-drug resistance against several classes of antibiotics. Capsular polysaccharide …

Association of capsular polysaccharide locus 2 with prognosis of Acinetobacter baumannii bacteraemia

JL Yang, CJ Yang, YC Chuang, WH Sheng… - Emerging Microbes & …, 2022 - Taylor & Francis
Acinetobacter baumannii causes healthcare-associated infections worldwide. Capsular
polysaccharide (CPS) is shown an important virulence factor of A. baumannii both in vitro …

Guanidine Additive Enabled Intermolecular ortho‐Phthalaldehyde‐Amine‐Thiol Three‐Component Reactions for Modular Constructions

CHP Cheung, TH Chong, T Wei, H Liu… - Angewandte …, 2023 - Wiley Online Library
Abstract Recently, ortho‐phthalaldehyde (OPA) is experiencing a renascence for the
modification of proteins and peptides through OPA‐amine two‐component reactions for …