Podophyllotoxin, along with its various derivatives and congeners are widely recognized as
broad-spectrum pharmacologically active compounds. Etoposide, for instance, is the …

Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …

A series of forty different pyrazole containing benzimidazole hybrids (6–45) have been
designed, synthesized and evaluated for their potential anti-proliferative activity against …

This review article proposes a comprehensive report of the design strategies engaged in the
development of various sulfur‐bearing cytotoxic agents. The outcomes of various studies …

Topoisomerases (topo-I and topo-II) have occupied a significant role in DNA replication,
transcription, and are a promising set of antitumor targets. In the present approach, a series …

Human papillomavirus (HPV) is the most common sexually transmitted disease. Via infection
of the basal epithelial cells, HPV causes numerous malignancies and noncancerous …

A series of new (Z)-3-(3′-methoxy-4′-(2-amino-2-oxoethoxy) benzylidene) indolin-2-one
derivatives has been synthesized and evaluated for their cytotoxic activity against selected …

Microtubules are involved in many critical cellular processes including cell division, cell
shape maintenance, vesicle transportation and motility regulation. Disruption of tubulin …

Caesalpinia coriaria (C. coriaria), also named cascalote, has been known traditionally in
México for having cicatrizing and inflammatory properties. Phytochemical reports on …

Cancer patients need better anticancer drugs, and medicinal chemistry can play a critical
role in the discovery of these drugs. For an efficient drug discovery process, chemists …