The tetrahydroisoquinoline (THIQ) natural products constitute one of the largest families of
alkaloids and exhibit a wide range of structural diversity and biological activity. Ranging from …

Over the past few decades, the advent of C–H activation has led to a rethink among
chemists about the synthetic strategies employed for multi-step transformations. Indeed …

Conspectus Nitrogen heterocycles are present in approximately 60% of drugs, with
nonplanar heterocycles incorporating stereogenic centers being of considerable interest to …

C− H activation is an attractive methodology to increase molecular complexity without
requiring substrate prefunctionalization. In contrast to well‐established cross‐coupling …

This chapter provides a short overview of the history of morphine since it's isolation by
Sertürner in 1805. The biosynthesis of the title alkaloid as well as all total and formal …

The Illicium sesquiterpenes are a family of natural products containing over 100 highly
oxidized and structurally complex members, many of which display interesting biological …

The US Food and Drug Administration approved 18 new drugs that incorporate the
cyclopropyl structural motif in the time frame from 2012 to 2018. This review provides an …

Herein, we describe the development of a deconstructive strategy for the first asymmetric
synthesis of (−)‐thebainone A, capitalizing on an enantioselective C− C bond activation and …

A three-step process for the enantioselective assembly of cis-fused
octahydrophenanthrenes with a quaternary stereocenter is reported. This synthetic strategy …

As one of the largest and most representative families of natural medicines harvested from
plants, the mass production of opioids legitimately occupies large, worldwide farmland …