Lung cancer has shown a decrease in incidence and mortality in recent decades; however,
it remains one of the cancers with the highest incidence and ranks first in cancerrelated …

Lung cancer is a leading cause of cancer-related mortality worldwide, and is classically
divided into two major histological subtypes: non-small-cell lung cancer (NSCLC) and small …

Fibroblast growth factors (fgfs) are widely believed to activate their receptors by mediating
receptor dimerization. Here we show, however, that the FGF receptors form dimers in the …

Background Immune system evasion, distance tumor metastases, and increased cell
proliferation are the main reasons for the progression of non-small cell lung cancer (NSCLC) …

Simple Summary Deregulation of the FGF/FGFR axis is associated with many types of
cancer and contributes to the development of chemoresistance, limiting the effectiveness of …

ABSTRACT Fibroblast Growth Factor (FGF) ligands and their receptors are crucial factors
driving chemoresistance in several malignancies, challenging the efficacy of currently …

Background We report here a phase 1 study of LY2874455, a potent oral selective pan-
fibroblast growth factor receptor (FGFR) inhibitor. Objective The primary objective was to …

Introduction There is substantial evidence for the oncogenic effects of fibroblast growth factor
receptor 1 (FGFR1) in many types of cancer, including lung cancer, but the role of this …

Inhibitors of fibroblast growth factor receptor (FGFR) signaling have been investigated in
various human cancer diseases. Recently, the first compounds received FDA approval in …

According to the latest statistics from the International Agency for Research on Cancer
(IARC), lung cancer is one of the most lethal malignancies in the world, accounting for …