Flavonoids improve type 2 diabetes mellitus and its complications: A review

X Yi, M Dong, N Guo, J Tian, P Lei, S Wang… - Frontiers in …, 2023 - frontiersin.org
The prevalence of type 2 diabetes mellitus (T2DM) is increasing every year. Medications are
currently the most common therapy for T2DM. However, these medications have certain …

A narrative review on the mechanism of natural flavonoids in improving glucolipid metabolism disorders

W Niu, Y Feng, M Peng, J Cai - Phytotherapy Research, 2024 - Wiley Online Library
Glucolipid metabolism disorder (GLMD) is a complex chronic disease characterized by
glucose and lipid metabolism disorders with a complex and diverse etiology and rapidly …

Naringin prevents diabetic-induced dysmetabolism in male wistar rats by modulating GSK-3 activities and oxidative stress-dependent pathways

KB Okesina, AF Odetayo, WJ Adeyemi… - Cell biochemistry and …, 2024 - Springer
Type 2 diabetes mellitus (T2DM), characterized by insulin resistance and glucose
dysmetabolism, is a major metabolic disorder accompanied with health and financial …

[HTML][HTML] Biological activities, Molecular mechanisms, and Clinical application of Naringin in Metabolic syndrome

J Chen, X Qin, M Chen, T Chen, Z Chen, B He - Pharmacological Research, 2024 - Elsevier
Metabolic syndrome has become major health problems in recent decades, and natural
compounds receive considerable attention in the management of metabolic syndrome …

Nur77 is involved in the regulation of obesity‐related lower muscle mass by promoting Pten degradation

F Chen, Y Yu, H Tian, G Ma, R Ma, T Tian… - The FASEB …, 2023 - Wiley Online Library
Obesity may impair muscle function and is sometimes associated with lower muscle mass.
However, the internal regulatory mechanism is still unclear. Nur77 has been reported to …

Tea seed saponin‑reduced extract ameliorates palmitic acid‑induced insulin resistance in HepG2 cells

SC Cho, SY Shaw - Molecular Medicine Reports, 2023 - spandidos-publications.com
Tea (Camellia sinensis) seed cake is a potential resource that contains a wealth of bioactive
compounds. However, the high toxicity of tea saponins in tea seed cake restricts its …

Naringin, neohesperidin and their corresponding dihydrochalcones as bioactive substances: a symphony of bitter–sweet

R Wang, W You, H Lin, Y Cao, C Xu… - Food Quality and …, 2023 - academic.oup.com
Bitter is generally undesirable, although it is an important part of flavor. Bitter substances
exhibit diverse health-promoting activities, which is in line with the famous Chinese saying 'a …

Plant‐Derived Treatments for Different Types of Muscle Atrophy

X Wang, X Tang, Y Wang, S Zhao, N Xu… - Phytotherapy …, 2025 - Wiley Online Library
With the development of medicine and chemistry, an increasing number of plant‐derived
medicines have been shown to exert beneficial therapeutic on the treatment of various …

Endothelin-1 impairs skeletal muscle myogenesis and development via ETB receptors and p38 MAPK signaling pathway

SY Liu, LK Chen, YT Jhong, CW Chen… - Clinical …, 2024 - portlandpress.com
Myopenia is a condition marked by progressive decline of muscle mass and strength and is
associated with aging or obesity. It poses the risk of falling, with potential bone fractures …

The myokine CCL5 recruits subcutaneous preadipocytes and promotes intramuscular fat deposition in obese mice

W Yu, Y Yao, N Ye, Y Zhao, Z Ye… - … of Physiology-Cell …, 2024 - journals.physiology.org
Intramuscular fat (IMF) refers to the lipid stored in skeletal muscle tissue. The number and
size of intramuscular adipocytes are the primary factors that regulate IMF content …