While proteins populating their native conformations constitute the functional entities of cells,
protein aggregates are traditionally associated with cellular dysfunction, stress and disease …

Proteostasis can be disturbed by mutations affecting folding and stability of the encoded
protein. An example is the ubiquitin ligase Parkin, where gene variants result in autosomal …

J-domain proteins (JDPs) are the largest family of chaperones in most organisms, but much
of how they function within the network of other chaperones and protein quality control …

Parkinson's disease (PD) is a common and incurable neurodegenerative disorder that
arises from the loss of dopaminergic neurons in the substantia nigra and is mainly …

Protein degradation is a highly regulated cellular process crucial to enable the high dynamic
range of the response to external and internal stimuli and to balance protein biosynthesis to …

Protein quality control (PQC) mechanisms are essential for degradation of misfolded or
dysfunctional proteins. An essential part of protein homeostasis is recognition of defective …

ARGONAUTE (AGO) proteins bind to small non-coding RNAs to form RNA-induced
silencing complexes. In the RNA-bound state, AGO is stable while RNA-free AGO turns over …

Unstable proteins are prone to form non-native interactions with other proteins and thereby
may become toxic. To mitigate this, destabilized proteins are targeted by the protein quality …

N-Myc is a key driver of neuroblastoma and neuroendocrine prostate cancer (NEPC). One
potential way to circumvent the challenge of undruggable N-Myc is to target the protein …

Gene variants resulting in insertions or deletions of amino acid residues (indels) have
important consequences for evolution and are often linked to disease, yet, compared to …