Microglia are the primary immune cells of the central nervous system that help nourish and
support neurons, clear debris, and respond to foreign stimuli. Greatly impacted by their …

Alzheimer's disease (AD) is one of the looming health crises of the near future. Increasing
lifespans and better medical treatment for other conditions mean that the prevalence of this …

According to the WHO, the proportion of people over 60 years is increasing and expected to
reach 22% of total world's population in 2050. In parallel, recent animal demographic …

Oxidative damage in the brain may lead to cognitive impairments in aged humans. Further,
in age-associated neurodegenerative disease, oxidative damage may be exacerbated and …

Aged companion dogs with canine cognitive dysfunction (CCD) spontaneously develop
varying degrees of progressive cognitive decline and particular neuropathological features …

Canine cognitive dysfunction syndrome (CCDS) is a progressive neurodegenerative
disorder in senior dogs that is mainly associated with decreased ability to learn and respond …

The most common animal models currently used for Alzheimer disease (AD) research are
transgenic mice that express a mutant form of human Aβ precursor protein (APP) and/or …

Alzheimer's disease (AD) is a significant burden for human health that is increasing in
prevalence as the global population ages. There is growing recognition that current …

This article reviews canine and feline brain aging. Several key features are discussed and
compared, including general aging characteristics and neuropathology. Aging dogs and …

Brain insulin resistance is associated with an increased Aβ production in AD although the
molecular mechanisms underlying this link are still largely unknown. Biliverdin reductase-A …