Exchange-transferred NOE spectroscopy and bound ligand structure determination
CB Post - Current opinion in structural biology, 2003 - Elsevier
The exchange-transferred nuclear Overhauser effect of NMR spectroscopy provides
information on small-molecule ligands in association with high-molecular-weight proteins or …
information on small-molecule ligands in association with high-molecular-weight proteins or …
Thirty years of molecular dynamics simulations on posttranslational modifications of proteins
Posttranslational modifications (PTMs) are an integral component to how cells respond to
perturbation. While experimental advances have enabled improved PTM identification …
perturbation. While experimental advances have enabled improved PTM identification …
Conformational changes in protein loops and helices induced by post-translational phosphorylation
ES Groban, A Narayanan… - PLoS computational …, 2006 - journals.plos.org
Post-translational phosphorylation is a ubiquitous mechanism for modulating protein activity
and protein-protein interactions. In this work, we examine how phosphorylation can …
and protein-protein interactions. In this work, we examine how phosphorylation can …
Identification of a motif in the acetylcholine receptor β subunit whose phosphorylation regulates rapsyn association and postsynaptic receptor localization
LS Borges, S Yechikhov, YI Lee, JB Rudell… - Journal of …, 2008 - Soc Neuroscience
At the neuromuscular junction, the acetylcholine receptor (AChR) is specifically clustered in
the postsynaptic membrane via interactions with rapsyn and other scaffolding proteins …
the postsynaptic membrane via interactions with rapsyn and other scaffolding proteins …
Are dopamine D2 receptors out of control in psychosis?
P Seeman - Progress in Neuro-Psychopharmacology and …, 2013 - Elsevier
It is known that schizophrenia patients are behaviorally supersensitive to dopamine-like
drugs (amphetamine, methylphenidate). There is evidence for an increased release of …
drugs (amphetamine, methylphenidate). There is evidence for an increased release of …
Competition between intramolecular hydrogen bonds and solvation in phosphorylated peptides: simulations with explicit and implicit solvent
SE Wong, K Bernacki, M Jacobson - The Journal of Physical …, 2005 - ACS Publications
The atomic-level mechanisms of protein regulation by post-translational phosphorylation
remain poorly understood, except in a few well-studied systems. Molecular mechanics …
remain poorly understood, except in a few well-studied systems. Molecular mechanics …
Monoclonal Antibodies to Esophageal Cancer–Related Gene2 Protein
G Huang, D Wang, L Guo, N Zhao, Y Li, SH Lu - Hybridoma, 2005 - liebertpub.com
Esophageal cancer related gene2 (ECRG2) acts as a bi-functional gene associated with
regulation of cell growth and death, and plays an important role in carcinogenesis of …
regulation of cell growth and death, and plays an important role in carcinogenesis of …
Intracellular domains of the δ-subunits of Torpedo and rat acetylcholine receptors—expression, purification, and characterization
D Kottwitz, V Kukhtina, N Dergousova, T Alexeev… - Protein expression and …, 2004 - Elsevier
There are quite detailed structural data on the extracellular ligand-binding domain and the
intramembrane channel-forming domain of the nicotinic acetylcholine receptors (nAChR) …
intramembrane channel-forming domain of the nicotinic acetylcholine receptors (nAChR) …
Conformational analysis of drugs by nuclear magnetic resonance spectroscopy
1D, 2D, 3D one-, two-, three-dimensional CCR cross-correlated relaxation DG distance
geometry calculations DMSO dimethylsulfoxide E. COSY exclusive correlation spectroscopy …
geometry calculations DMSO dimethylsulfoxide E. COSY exclusive correlation spectroscopy …
Epitope mapping of the phosphorylation motif of the HIV-1 protein Vpu bound to the selective monoclonal antibody using TRNOESY and STD NMR spectroscopy
J Gharbi-Benarous, G Bertho, N Evrard-Todeschi… - Biochemistry, 2004 - ACS Publications
The conformational preferences of a 22-amino acid peptide (LIDRLIERAED pS GNE pS
EGEISA) that mimics the phosphorylated HIV-1-encoded virus protein U (Vpu) antigen have …
EGEISA) that mimics the phosphorylated HIV-1-encoded virus protein U (Vpu) antigen have …