Dual roles of prolactin and vasoinhibin in inflammatory arthritis

C Clapp, G Ortiz, JF García-Rodrigo… - Frontiers in …, 2022 - frontiersin.org
The term inflammatory arthritis defines a family of diseases, including rheumatoid arthritis
(RA), caused by an overactive immune system, and influenced by host aspects including …

Vasoinhibin's Apoptotic, Inflammatory, and Fibrinolytic Actions Are in a Motif Different From Its Antiangiogenic HGR Motif

JP Robles, M Zamora, JF Garcia-Rodrigo… - …, 2024 - academic.oup.com
Vasoinhibin, a proteolytic fragment of the hormone prolactin, inhibits blood vessel growth
(angiogenesis) and permeability, stimulates the apoptosis and inflammation of endothelial …

Thrombin cleaves prolactin into a potent 5.6-kDa vasoinhibin: implication for tissue repair

M Zamora, JP Robles, MB Aguilar… - …, 2021 - academic.oup.com
Vasoinhibin is an endogenous prolactin (PRL) fragment with profibrinolytic,
antivasopermeability, and antiangiogenic effects. The fact that blood clotting, vascular …

The HGR motif is the antiangiogenic determinant of vasoinhibin: implications for a therapeutic orally active oligopeptide

JP Robles, M Zamora, L Siqueiros-Marquez… - Angiogenesis, 2022 - Springer
The hormone prolactin acquires antiangiogenic and antivasopermeability properties after
undergoing proteolytic cleavage to vasoinhibin, an endogenous prolactin fragment of 123 or …

Topical Ophthalmic Administration of VIAN-c4551 Antiangiogenic Peptide for Diabetic Macular Edema: Preclinical Efficacy and Ocular Pharmacokinetics

E Adán-Castro, M Zamora, D Granados-Carrasco… - bioRxiv, 2024 - biorxiv.org
VIAN-c4551 is a cyclic antiangiogenic peptide that stands as a potent and stable inhibitor of
vascular endothelial cell growth factor (VEGF), the major vasopermeability and angiogenic …

Condon Optimization: Codon Optimization of Therapeutic Proteins: Suggested Criteria for Increased Efficacy and Safety

VP Mauro - … Nucleotide Polymorphisms: Human Variation and a …, 2022 - Springer
Proteins are amongst the most useful and effective molecules for a range of applications,
including industrial enzymes and therapeutics. Some proteins can be purified from natural …

The apoptotic, inflammatory, and fibrinolytic actions of vasoinhibin are in a motif different from its antiangiogenic HGR motif

JP Robles, M Zamora, JF Garcia-Rodrigo, AL Perez… - bioRxiv, 2023 - biorxiv.org
Vasoinhibin is a proteolytic fragment of the hormone prolactin that inhibits blood vessel
growth (angiogenesis) and permeability, stimulates the apoptosis and inflammation of …

[PDF][PDF] ESCUELA NACIONAL DE ESTUDIOS SUPERIORES UNIDAD JURIQUILLA

EYVDEL MONTAJE - 2023 - ru.dgb.unam.mx
Este trabajo describe los antecedentes y procesos para las condiciones más ideales del
montaje de una técnica cromatográfica y de detección del neurotransmisor histamina; de tal …

[PDF][PDF] IDENTIFICACIÓN DEL DETERMINANTE FUNCIONAL DE LA VASOINHIBINA: IMPLICACIONES TERAPÉUTICAS Y FISIOLÓGICAS

DRJPR ÁLVAREZ - 2023 - ru.dgb.unam.mx
La hormona prolactina adquiere propiedades inhibitorias sobre la proliferación
(angiogénesis) y permeabilidad de los vasos sanguíneos después de ser procesada …