Video Abstract CONTEXT Adverse childhood experiences (ACEs) are associated with
increased risk of poor mental health outcomes. Although there is interest in screening for …

Emerging evidence suggests that partially distinct mechanisms may underlie the association
between different dimensions of early life adversity (ELA) and psychopathology in children …

Importance A history of childhood maltreatment is associated with an unfavorable course of
illness for emotional disorders. However, the origins and mechanisms underlying these …

Exposure to adversity in childhood is associated with elevations in numerous physical and
mental health outcomes across the life course. The biological embedding of early …

Children who experience adversities have an elevated risk of mental health problems.
However, the extent to which adverse childhood experiences (ACEs) cause mental health …

Disrupted operations of the reward circuit underlie major emotional disorders, including
depression, which commonly arise following early life stress/adversity (ELA). However, how …

People exposed to more unfavourable social circumstances are more vulnerable to poor
mental health over their life course, in ways that are often determined by structural factors …

Social nonhuman animals are powerful models for studying underlying factors related to
lifelong health outcomes following early life adversities (ELAs). ELAs can be linked to …

Adverse childhood experiences (ACEs) lead to excess morbidity and mortality. However,
this evidence has not resulted in large-scale efforts to prevent ACEs. We conducted a …

Decades of research underscore the profound impact of adversity on brain and behavioral
development. Recent theoretical models have highlighted the importance of considering …