Drug-resistant fungi: an emerging challenge threatening our limited antifungal armamentarium

A Arastehfar, T Gabaldón, R Garcia-Rubio, JD Jenks… - Antibiotics, 2020 - mdpi.com
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs),
along with significant agricultural crop loss caused by various fungal species, has resulted in …

Invasive candidiasis: current clinical challenges and unmet needs in adult populations

A Soriano, PM Honore, P Puerta-Alcalde… - Journal of …, 2023 - academic.oup.com
Invasive candidiasis (IC) is a serious infection caused by several Candida species, and the
most common fungal disease in hospitals in high-income countries. Despite overall …

Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project

M Bassetti, DR Giacobbe, A Vena, C Trucchi, F Ansaldi… - Critical Care, 2019 - Springer
Background The objective of this study was to assess the cumulative incidence of invasive
candidiasis (IC) in intensive care units (ICUs) in Europe. Methods A multinational …

ESICM/ESCMID task force on practical management of invasive candidiasis in critically ill patients

I Martin-Loeches, M Antonelli, M Cuenca-Estrella… - Intensive care …, 2019 - Springer
Introduction The term invasive candidiasis (IC) refers to both bloodstream and deep-seated
invasive infections, such as peritonitis, caused by Candida species. Several guidelines on …

What has changed in the treatment of invasive candidiasis? A look at the past 10 years and ahead

M Bassetti, E Righi, P Montravers… - Journal of Antimicrobial …, 2018 - academic.oup.com
The treatment of invasive candidiasis has changed greatly in the past decade and must
continue to evolve if we are to improve outcomes in this serious infection. A review of recent …

The risk and clinical outcome of candidemia depending on underlying malignancy

O Lortholary, C Renaudat, K Sitbon… - Intensive care …, 2017 - Springer
Purpose To assess the risk factors and outcomes associated with fungemia caused by the
six most commonly occurring Candida species in patients with and without malignancies …

Diagnosis and management of invasive candidiasis in the ICU: an updated approach to an old enemy

T Calandra, JA Roberts, M Antonelli, M Bassetti… - Critical Care, 2016 - Springer
Invasive fungal infections, particularly those caused by Candida species, are not uncommon
in critically ill patients and are associated with considerable morbidity and mortality …

[HTML][HTML] Antifungal prophylaxis and pre-emptive therapy: When and how?

R Sprute, JA Nacov, D Neofytos, M Oliverio… - Molecular aspects of …, 2023 - Elsevier
The growing pool of critically ill or immunocompromised patients leads to a constant
increase of life-threatening invasive infections by fungi such as Aspergillus spp., Candida …

The current treatment landscape: candidiasis

M Bassetti, M Peghin, JF Timsit - Journal of Antimicrobial …, 2016 - academic.oup.com
The epidemiology of Candida species infection has changed over recent decades,
influenced by local hospital-related factors, patient predisposing conditions and type of …

(1,3)-β-d-Glucan-based empirical antifungal interruption in suspected invasive candidiasis: a randomized trial

G De Pascale, B Posteraro, S D'Arrigo, G Spinazzola… - Critical Care, 2020 - Springer
Abstract Background (1, 3)-β-d-Glucan has been widely used in clinical practice for the
diagnosis of invasive Candida infections. However, such serum biomarker showed potential …