[HTML][HTML] Central chemoreceptors: locations and functions
E Nattie, A Li - Comprehensive physiology, 2012 - ncbi.nlm.nih.gov
Central chemoreception traditionally refers to a change in ventilation attributable to changes
in CO 2/H+ detected within the brain. Interest in central chemoreception has grown …
in CO 2/H+ detected within the brain. Interest in central chemoreception has grown …
Central chemoreception is a complex system function that involves multiple brain stem sites
E Nattie, A Li - Journal of applied physiology, 2009 - journals.physiology.org
CENTRAL CHEMORECEPTION refers to detection of CO2/pH within the brain and the
subsequent reflex effects on breathing. It involves multiple sites within the hindbrain (9, 12 …
subsequent reflex effects on breathing. It involves multiple sites within the hindbrain (9, 12 …
The cells and logic for mammalian sour taste detection
Mammals taste many compounds yet use a sensory palette consisting of only five basic taste
modalities: sweet, bitter, sour, salty and umami (the taste of monosodium glutamate) …
modalities: sweet, bitter, sour, salty and umami (the taste of monosodium glutamate) …
Expression of Phox2b by brainstem neurons involved in chemosensory integration in the adult rat
RL Stornetta, TS Moreira, AC Takakura… - Journal of …, 2006 - Soc Neuroscience
Central congenital hypoventilation syndrome is caused by mutations of the gene that
encodes the transcription factor Phox2b. The syndrome is characterized by a severe form of …
encodes the transcription factor Phox2b. The syndrome is characterized by a severe form of …
Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons
Serotonergic neurons project widely throughout the CNS and modulate many different brain
functions. Particularly important, but controversial, are the contributions of serotonin (5-HT) …
functions. Particularly important, but controversial, are the contributions of serotonin (5-HT) …
Peripheral chemoreceptor inputs to retrotrapezoid nucleus (RTN) CO2‐sensitive neurons in rats
The rat retrotrapezoid nucleus (RTN) contains pH‐sensitive neurons that are putative central
chemoreceptors. Here, we examined whether these neurons respond to peripheral …
chemoreceptors. Here, we examined whether these neurons respond to peripheral …
A genetically defined circuit for arousal from sleep during hypercapnia
The precise neural circuitry that mediates arousal during sleep apnea is not known. We
previously found that glutamatergic neurons in the external lateral parabrachial nucleus …
previously found that glutamatergic neurons in the external lateral parabrachial nucleus …
Raphe neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P
K Ptak, T Yamanishi, J Aungst, LS Milescu… - Journal of …, 2009 - Soc Neuroscience
Brainstem serotonin (5-HT) neurons modulate activity of many neural circuits in the
mammalian brain, but in many cases endogenous mechanisms have not been resolved …
mammalian brain, but in many cases endogenous mechanisms have not been resolved …
A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons
V Dubreuil, N Ramanantsoa… - Proceedings of the …, 2008 - National Acad Sciences
Breathing is maintained and controlled by a network of neurons in the brainstem that
generate respiratory rhythm and provide regulatory input. Central chemoreception, the …
generate respiratory rhythm and provide regulatory input. Central chemoreception, the …
Afferent and efferent connections of the rat retrotrapezoid nucleus
DL Rosin, DA Chang… - Journal of Comparative …, 2006 - Wiley Online Library
The rat retrotrapezoid nucleus (RTN) contains candidate central chemoreceptors that have
extensive dendrites within the marginal layer (ML). This study describes the axonal …
extensive dendrites within the marginal layer (ML). This study describes the axonal …