The life of every organism is dependent on the fine-tuned mechanisms of protein synthesis
and breakdown. The degradation of most intracellular proteins is performed by the ubiquitin …

DJ-1 is a cancer-and Parkinson's disease-associated protein that participates in different
intracellular signaling pathways to protect cells from toxic stresses. DJ-1 expression …

Cervical cancer is one of the most common gynecological malignancies with poor prognosis
due to constant chemoresistance and repeated relapse. Ciclopirox olamine (CPX), a …

The growing interest in the application of proteomic technologies to solve toxicology issues
and its relevance in ecotoxicology research has resulted in the emergence of …

Background Uveal melanoma (UM) is the most common primary intraocular malignancy in
adults. Many previous studies have demonstrated that the infiltrating of immune and stromal …

A major hallmark of pancreatic ductal adenocarcinoma (PDAC) is extensive local tumor
invasion and early systemic dissemination. DJ-1 has been shown to prevent cell death via …

Psoriasis is a chronic inflammatory skin disease characterized by abnormal proliferation of
epidermal keratinocytes and infiltration of inflammatory cells. CRNN is a major component of …

Genital infection by high risk Human Papillomavirus (HR-HPV), although recognized as the
main etio-pathogenetic factor of cervical cancer, is not per se sufficient to induce tumour …

Metastatic dissemination of primary tumors is responsible for 90% of colorectal cancer
(CRC) deaths. The presence of positive lymph nodes, which separates stage I/II from stage …

The expression of PARK7 is upregulated in various types of cancer, suggesting its potential
role as a critical regulator of the pathogenesis of cancer and in the treatment of cancer and …