Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

Since the emergence of regenerative medicine and tissue engineering more than half a
century ago, one obstacle has persisted: the in vitro creation of large-scale vascular tissue (> …

Collagen has shown promising potential in biomedical fields due to its high biocompatibility,
abundance of resources, ease of flexible modification, and potential for active targeting. The …

Coronary heart disease (CHD) is caused by narrowing or blockage of coronary arteries due
to atherosclerosis. Coronary artery bypass grafting (CABG) is widely used for the treatment …

Induced pluripotent stem cells (iPSCs) are remarkable scientific advances in both
regenerative and personalized medicine. Since they were first reported in 2006, iPSCs have …

Many pathologies, congenital defects, and traumatic injuries are untreatable by conventional
pharmacologic or surgical interventions. Regenerative engineering represents an ever …

Tissue-engineered vascular conduits (TEVCs), often made by seeding autologous bone
marrow cells onto biodegradable polymeric scaffolds, hold promise toward treating single …

Small-caliber tissue-engineered vascular grafts (TEVGs, luminal diameter< 6 mm) are
promising therapies for coronary or peripheral artery bypassing surgeries or emergency …

The clinical demand for tissue-engineered vascular grafts is still rising, and there are many
challenges that need to be overcome, in particular, to obtain functional small-diameter grafts …

Endothelial cells derived from human induced pluripotent stem cells (hiPSC-ECs) provide a
new opportunity for mechanistic research on vascular regeneration and drug screening …