Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved
from a binding site with unknown function to a firmly established major effector within the …

Depression remains a debilitating condition with an uncertain aetiology. Recently, attention
has been given to the renin–angiotensin system. In the central nervous system, angiotensin …

Abstract See Moon (doi: 10.1093/awv239) for a scientific commentary on this article.
Traumatic brain injury frequently leads to long-term cognitive problems and physical …

Although angiotensin II subtype-2 receptor (AT2R) was discovered over 2 decades ago, its
contribution to physiology and pathophysiology is not fully elucidated. Current knowledge …

Besides assisting the maintenance of blood pressure and sodium homeostasis, the renin-
angiotensin system (RAS) plays a pivotal role in pathogenesis of acute kidney injury (AKI) …

The discovery of beneficial neuroprotective effects of the angiotensin converting enzyme 2–
angiotensin-(1-7)–Mas axis [ACE2–Ang-(1-7)–Mas] in ischemic and hemorrhagic stroke has …

A disabling consequence of stroke is cognitive impairment, occurring in 12%–48% of
patients, for which there is no therapy. A critical barrier is the lack of understanding of how …

Abstract Purpose of Review Although an independent brain renin-angiotensin system is
often assumed to exist, evidence for this concept is weak. Most importantly, renin is lacking …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is responsible for
the global corona virus disease 2019 (COVID-19) pandemic enters host cells via a …

Angiotensin-II acts at its type-1 receptor (AT1R) in the brain to regulate body fluid
homeostasis, sympathetic outflow and blood pressure. However, the role of the angiotensin …