Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond: from mechanism to pharmacotherapies

S Xu, I Ilyas, PJ Little, H Li, D Kamato, X Zheng… - Pharmacological …, 2021 - Elsevier
The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in
maintaining multiorgan health and homeostasis. Endothelial functions in health include …

Signaling pathways and intervention therapies in sepsis

Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Vascular endothelium–gatekeeper of vessel health

PA Cahill, EM Redmond - Atherosclerosis, 2016 - Elsevier
The vascular endothelium is an interface between the blood stream and the vessel wall.
Changes in this single cell layer of the artery wall are believed of primary importance in the …

Protein interactions at endothelial junctions and signaling mechanisms regulating endothelial permeability

YA Komarova, K Kruse, D Mehta, AB Malik - Circulation research, 2017 - Am Heart Assoc
The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …

Sphingolipid metabolites in inflammatory disease

M Maceyka, S Spiegel - Nature, 2014 - nature.com
Sphingolipids are ubiquitous building blocks of eukaryotic cell membranes. Progress in our
understanding of sphingolipid metabolism, state-of-the-art sphingolipidomic approaches …

Passing the vascular barrier: endothelial signaling processes controlling extravasation

N Wettschureck, B Strilic… - Physiological …, 2019 - journals.physiology.org
A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

Sphingosine 1-phosphate and inflammation

H Obinata, T Hla - International immunology, 2019 - academic.oup.com
Abstract AbstractSphingosine 1-phosphate (S1P), a sphingolipid mediator, regulates various
cellular functions via high-affinity G protein-coupled receptors, S1P1-5. The S1P-S1P …

An update on the biology of sphingosine 1-phosphate receptors

VA Blaho, T Hla - Journal of lipid research, 2014 - ASBMB
Sphingosine 1-phosphate (S1P) is a membrane-derived lysophospholipid that acts primarily
as an extracellular signaling molecule. Signals initiated by S1P are transduced by five G …

The outs and the ins of sphingosine-1-phosphate in immunity

S Spiegel, S Milstien - Nature Reviews Immunology, 2011 - nature.com
The potent lipid mediator sphingosine-1-phosphate (S1P) is produced inside cells by two
closely related kinases, sphingosine kinase 1 (SPHK1) and SPHK2, and has emerged as a …

Endothelium—role in regulation of coagulation and inflammation

VWM van Hinsbergh - Seminars in immunopathology, 2012 - Springer
By its strategic position at the interface between blood and tissues, endothelial cells control
blood fluidity and continued tissue perfusion while simultaneously they direct inflammatory …