Leishmaniasis is a tropical infectious disease caused by the protozoan Leishmania parasite.
The disease is transmitted by female sand flies and, depending on the infecting parasite …

Interferon (IFN)-inducible guanylate binding proteins (GBPs) play important roles in host
defense against many intracellular pathogens that reside within pathogen-containing …

Monitoring the drug susceptibility of Leishmania isolates still largely relies on standard in
vitro cell-based susceptibility assays using (patient-isolated) promastigotes for infection …

Leishmania (Mundinia) martiniquensis is a causative agent of visceral leishmaniasis, but in
HIV-infected patients both visceral and disseminated cutaneous leishmaniasis are …

The dynamic interaction between the host and pathogens, along with environmental factors,
influences the regulation of mammalian immune responses. Therefore, comprehensive in …

The application of in vivo bioluminescent imaging in infectious disease research has
significantly increased over the past years. The detection of transgenic parasites expressing …

This chapter describes a viability assay for the intracellular (amastigote) and clinically
relevant form of Leishmania infantum that is based on the detection of bioluminescence (BL) …

Abstract T-complex protein-1 (TCP1) is a group II chaperonin, known to fold various proteins
like actin and tubulin. In Leishmania donovani only one subunit that is gamma subunit …

Leishmaniasis is a vector borne parasitic disease affecting millions of people worldwide and
is spreading into further areas because of global warming. The development of new active …

Type I interferons (IFNs) induced by an endogenous Leishmania RNA virus or exogenous
viral infections have been shown to exacerbate infections with New World Cutaneous …